Center for Medical Genomics

医学基因组学中心

• 批准号: 9793157
• 负责人: Yunlong Liu
• 金额: $ 12万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9793157
• 关键词: 16S ribosomal RNA sequencing; ATAC-seq; Advanced Malignant Neoplasm; Advisory Committees; Age; Alleles; Alternative Splicing; Animal Model; Bioinformatics; Biological Assay; Biology; Biomedical Research; CRISPR screen; Cancer Center; Cancer Center Support Grant; Cells; ChIP-seq; Chromium; Client; Committee Members; Complex; Computational Biology; DNA sequencing; Detection; Development; Disease; Education; Elements; Epigenetic Process; Exons; Gene Expression; Genes; Genomics; Genotype; High School Student; Human; Indiana; Ions; Lead; Libraries; Malignant Neoplasms; Measures; Medical center; Metagenomics; Methods; MicroRNAs; Microarray Analysis; Mission; Play; Preparation; Prevention approach; Price; Protocols documentation; Protons; RNA; Reporter; Research; Research Personnel; Running; Sampling; Science; Scientist; Services; Shotgun Sequencing; Single Nucleotide Polymorphism; Site; Surveys; System; Technology; Testing; Time; Training Activity; Universities; Variant; Vendor; Virus; anticancer research; base; bisulfite sequencing; cancer therapy; college; course module; crosslinking and immunoprecipitation sequencing; design; epigenomics; exome sequencing; experience; experimental study; functional genomics; genomic tools; human genome sequencing; individualized medicine; instrument; laser capture microdissection; mRNA sequencing; medical schools; member; new technology; next generation sequencing; novel; response; single-cell RNA sequencing; technology development; training opportunity; transcriptome; transcriptome sequencing; whole genome

ABSTRACT, Genomics Core (GC) With the sequencing of the human genome, biomedical sciences have entered the age of functional genomics. New technologies offer the promise of vastly increased understanding of biology, and through that of better approaches to the prevention and treatment of complex disease, including cancer. Next-generation sequencing (NGS) of DNA and RNA has become a powerful tool for genomics study. It allows detection and identification of known as well as novel variations at base level. It measures gene expression, allele-specific expression, epigenomic changes, and alternative splicing of whole transcriptome. Microarray technology is also powerful for experiments involving known gene elements. SNP genotyping allows confirmation of variations discovered in NGS. These state-of-the-art technologies provide comprehensive approaches for functional genomics in cancer research. Studies based on these genomic tools, both in humans and in model organisms, will lead cancer treatment into an era of more individualized treatments. The Genomics Core (GC) at Indiana University School of Medicine (IUSM) provides state-of-the-art genomics services to investigators at Indiana University Simon Cancer Center (IUSCC), including next generation sequencing, single-cell analytics, microarray and high-throughput genotyping. With decades of experience and strong track record in supporting cancer research, significant subsidization from IUSM and IUSCC, and strong ties with the Center for Computational Biology and Bioinformatics (CCBB), the GC strives to provide IUSCC members high-quality genomic services with fast-turnaround times at affordable prices.

摘要，基因组学核心 (GC) 随着人类基因组测序，生物医学科学进入了功能基因组学时代。 新技术有望大大增进对生物学的理解，并通过更好地了解生物学 预防和治疗包括癌症在内的复杂疾病的方法。新一代测序 DNA 和 RNA 的 NGS（NGS）已成为基因组学研究的强大工具。它允许检测和识别 基础层面上已知的以及新颖的变化。它测量基因表达、等位基因特异性表达、 表观基因组变化和整个转录组的选择性剪接。微阵列技术也很强大 涉及已知基因元件的实验。 SNP 基因分型可以确认在 NGS。这些最先进的技术为癌症功能基因组学提供了全面的方法 研究。基于这些基因组工具的研究，无论是在人类还是在模式生物中，都将导致癌症 治疗进入更加个体化治疗的时代。 印第安纳大学医学院 (IUSM) 的基因组学核心 (GC) 提供最先进的基因组学 为印第安纳大学西蒙癌症中心 (IUSCC) 的研究人员提供服务，包括下一代 测序、单细胞分析、微阵列和高通量基因分型。凭借数十年的经验和 在支持癌症研究方面的良好记录、IUSM 和 IUSCC 的大量补贴以及强大的 与计算生物学和生物信息学中心 (CCBB) 合作，GC 致力于提供 IUSCC 会员提供高质量的基因组服务，周转时间短，价格实惠。