Neural development

神经发育

基本信息

批准号：
2413-2009
负责人：
Burke, Robert
金额：
$ 4.37万
依托单位：
University of Victoria
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2013
资助国家：
加拿大
起止时间：
2013-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=520479
关键词：
Neural development

项目摘要

I propose continuation of a research program in which the long term objective is to determine the underlying molecular mechanisms that pattern embryonic nervous systems. A series of studies are outlined in which I will test hypotheses on the embryonic origin of nerves, and the mechanisms by which Eph receptor and ephrin signaling guide migration of neural progenitor cells. These studies are to be carried out in sea urchin embryos - a model for studies in neurogenesis. My involvement with the sequencing and annotation of the sea urchin genome, experience with manipulation of gene expression, and a longstanding interest in neural development in urchin embryos makes this program unique. I propose support for a program to train students in modern developmental biology in which the precise roles of cell signalling molecules can be determined. These studies will contribute to fundamental questions of the role of cellular signaling in animal development. Sea urchins show close molecular kinship with vertebrates, yet they have a remarkably different body plan. Preliminary studies have revealed features that are shared with vertebrates providing an opportunity to contribute to our understanding of neural evolution. This is an established program of high-quality research that has been demonstrated to be a stimulating environment for research training. This research program will establish sea urchin embryos as a unique model for neural development with the potential to give new perspectives and insights to the function of Eph/ephrin signaling and evolution of neural development.

我提出了一个研究计划的延续，其中长期目标是确定对胚胎神经系统进行模拟的基本分子机制。概述了一系列的研究，其中我将对神经的胚胎起源进行测试，以及EPH受体和Ephrin信号指导神经祖细胞的迁移的机制。这些研究将在海胆胚胎中进行 - 神经发生研究的模型。我参与了海胆基因组的测序和注释，对基因表达的操纵经验以及对胆管胚胎神经发育的长期兴趣使该程序与众不同。我建议支持一个计划，以培训学生的现代发展生物学，其中可以确定细胞信号分子的精确作用。这些研究将导致细胞信号在动物发育中的作用的基本问题。海胆显示与脊椎动物的分子亲属关系，但它们的身体计划却非常不同。初步研究揭示了与脊椎动物共享的特征，从而提供了有助于我们对神经进化的理解的机会。这是一项既定的高质量研究计划，已被证明是研究培训的刺激性环境。该研究计划将建立海胆胚作为神经发育的独特模型，并有可能对EPH/Ephrin信号传导和神经发育的演变的功能提供新的观点和见解。