Design, manufacturing and testing of a left-heart simulator based on a passively beating porcine heart and compatible with ViVitro's Pulse Duplicator system

基于被动跳动的猪心脏并与 ViVitro 的脉冲复制器系统兼容的左心模拟器的设计、制造和测试

• 批准号: 484328-2015
• 负责人: Labrosse, Michel
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=584246
• 关键词: Design; manufacturing; testing; left; heart

ViVitro Labs Inc. seeks to enhance their line of research/development cardiovascular testing products to take advantage of the pulsatile pump and data acquisition systems found in their Pulse Duplicator while allowing the user to experiment on whole ex-vivo pig hearts. In such applications, the non-beating hearts would be simply harvested at a slaughterhouse and the pulsatile flow driven by the external pumping system. For users not primarily interested in prosthetic valves, ex-vivo pig hearts will make it possible to test medical devices and surgical procedures on the aortic and mitral valves with excellent anatomical fidelity. The objectives of the proposed project are to (iteratively) design, manufacture, test and prove the effectiveness of new mechanical components compatible with existing components of ViVitro's Pulse Duplicator system to achieve quick and reliable set-up of experiments on ex-vivo pig hearts. The applicant's Cardiovascular Mechanics Laboratory (CML) at the University of Ottawa secured the acquisition of one ViVitro Pulse Duplicator back in 2006, thanks to an NSERC RTI grant. Over the years, the applicant and his team have used the system in its original version, as well as after significant in-house modifications to enable testing of whole porcine aortic roots and valves. ViVitro's Pulse Duplicator has provided the experimental benchmark necessary for the CML to develop and validate several numerical models of the aortic valve, with increasing levels of complexity, accuracy and clinical relevance. Very opportunely, the CML is at a research point where it needs the very type of system that ViVitro wants to develop. By expanding the range of applicability of ViVitro's equipment, the proposed project will help ViVitro Labs Inc. acquire new market shares and bolster its position as a global leader. This will favourably impact Canada's economy and image as a technology driver.

Vivitro Labs Inc.试图增强其研究/开发的心血管测试产品线，以利用其脉冲重复器中发现的脉动​​泵和数据采集系统，同时允许用户对整个前体病毒心脏进行试验。在这种应用中，非伴随的心脏将简单地在屠宰场和由外部抽水系统驱动的脉动流中收获。对于主要对假体阀不感兴趣的用户，前体内猪心脏将有可能在具有出色的解剖学保真度的主动脉和二尖瓣上测试医疗设备和外科手术。 拟议项目的目标是（迭代）设计，制造，测试和证明与Vivitro Pulse Replicator系统现有组件兼容的新机械组件的有效性，以实现对Ex-Vivo Pig Hearts实验的快速可靠设置。 渥太华大学申请人的心血管力学实验室（CML），由于NSERC RTI赠款，2006年获得了一项Vivitro Pulse Replicator的收购。多年来，申请人及其团队在其原始版本中使用了该系统，并经过大量内部修改以实现整个猪主动脉根和阀门的测试。 Vivitro的Pulse Replicator提供了CML开发和验证多种主动脉瓣数的数值模型所需的实验基准，其复杂性，准确性和临床相关性的水平提高。非常合适的是，CML处于需要Vivitro想要开发的系统类型的研究点。 通过扩大Vivitro设备的适用性范围，该项目将帮助Vivitro Labs Inc.获取新的市场份额并增强其作为全球领导者的地位。这将对加拿大作为技术驱动力的经济和形象有利。