Design, manufacturing and testing of a left-heart simulator based on a passively beating porcine heart and compatible with ViVitro's Pulse Duplicator system

基于被动跳动的猪心脏并与 ViVitro 的脉冲复制器系统兼容的左心模拟器的设计、制造和测试

• 批准号: 484328-2015
• 负责人: Labrosse, Michel
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=584246
• 关键词: Design; manufacturing; testing; left; heart

ViVitro Labs Inc. seeks to enhance their line of research/development cardiovascular testing products to take advantage of the pulsatile pump and data acquisition systems found in their Pulse Duplicator while allowing the user to experiment on whole ex-vivo pig hearts. In such applications, the non-beating hearts would be simply harvested at a slaughterhouse and the pulsatile flow driven by the external pumping system. For users not primarily interested in prosthetic valves, ex-vivo pig hearts will make it possible to test medical devices and surgical procedures on the aortic and mitral valves with excellent anatomical fidelity. The objectives of the proposed project are to (iteratively) design, manufacture, test and prove the effectiveness of new mechanical components compatible with existing components of ViVitro's Pulse Duplicator system to achieve quick and reliable set-up of experiments on ex-vivo pig hearts. The applicant's Cardiovascular Mechanics Laboratory (CML) at the University of Ottawa secured the acquisition of one ViVitro Pulse Duplicator back in 2006, thanks to an NSERC RTI grant. Over the years, the applicant and his team have used the system in its original version, as well as after significant in-house modifications to enable testing of whole porcine aortic roots and valves. ViVitro's Pulse Duplicator has provided the experimental benchmark necessary for the CML to develop and validate several numerical models of the aortic valve, with increasing levels of complexity, accuracy and clinical relevance. Very opportunely, the CML is at a research point where it needs the very type of system that ViVitro wants to develop. By expanding the range of applicability of ViVitro's equipment, the proposed project will help ViVitro Labs Inc. acquire new market shares and bolster its position as a global leader. This will favourably impact Canada's economy and image as a technology driver.

ViVitro Labs Inc. 寻求增强其研究/开发心血管测试产品系列，以利用其脉冲复制器中的脉动泵和数据采集系统，同时允许用户在整个离体猪心脏上进行实验。在此类应用中，只需在屠宰场收获不跳动的心脏，并由外部泵系统驱动脉动流。对于主要对人工瓣膜不感兴趣的用户来说，体外猪心脏将能够以出色的解剖保真度测试主动脉瓣和二尖瓣上的医疗设备和外科手术。 拟议项目的目标是（迭代）设计、制造、测试和证明与 ViVitro 脉冲复制器系统现有组件兼容的新机械组件的有效性，以实现快速可靠的离体猪心脏实验设置。 得益于 NSERC RTI 的资助，申请人位于渥太华大学的心血管力学实验室 (CML) 于 2006 年获得了一台 ViVitro 脉冲复制器。多年来，申请人和他的团队一直使用该系统的原始版本，以及经过重大内部修改后能够测试整个猪主动脉根部和瓣膜的系统。 ViVitro 的脉冲复制器为 CML 提供了开发和验证主动脉瓣数值模型所需的实验基准，其复杂性、准确性和临床相关性不断提高。非常巧的是，CML 正处于一个研究阶段，它需要 ViVitro 想要开发的系统类型。 通过扩大 ViVitro 设备的适用范围，拟议项目将帮助 ViVitro Labs Inc. 获得新的市场份额并巩固其全球领导者的地位。这将对加拿大的经济和作为技术驱动者的形象产生有利的影响。