Development of computational tools for patient-specific aortic valve repair simulation

开发用于患者特定主动脉瓣修复模拟的计算工具

基本信息

批准号：
312065-2012
负责人：
Labrosse, Michel
金额：
$ 1.89万
依托单位：
University of Ottawa
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571678
关键词：
Development computational tools patient specific

项目摘要

The number of patients with aortic valve disease keeps growing due to the aging of the population in Canada and elsewhere. Aortic valve repair can mitigate the impact of aortic valve disease on quality of life and life expectancy. The proposed research program aims to allow more patients to benefit from aortic valve repair by providing the majority of cardiac surgeons who are not experts in this procedure with reliable simulation tools to help them choose between different aortic valve repair techniques in a patient-specific manner. This choice will be based on mechanistic aspects such as overall valve function, mechanical stress level in the valvular components (i.e. a predictor of risk of immediate tissue tearing and/or long-term calcification), opening and closing characteristics, and sealing quality of the valve. In addition, new methods will be developed to reduce computational time. An aortic valve repair expert cardiac surgeon and a trained anesthesiologist and echocardiographer from the University of Ottawa Heart Institute have committed their continued participation to provide medical expertise and patient data, thereby maximizing the clinical relevance of the research program. Given the clinical and financial advantages of aortic valve repair over replacement, this will greatly benefit the Canadian healthcare system.

由于加拿大和其他地区的人口老龄化，主动脉瓣疾病患者的数量不断增加。主动脉瓣修复可以减轻主动脉瓣疾病对生活质量和预期寿命的影响。拟议的研究计划旨在通过为大多数不是该手术专家的心脏外科医生提供可靠的模拟工具，帮助他们以针对患者的方式在不同的主动脉瓣修复技术之间进行选择，从而让更多的患者从主动脉瓣修复中受益。这种选择将基于机械方面，例如整体瓣膜功能、瓣膜组件中的机械应力水平（即立即组织撕裂和/或长期钙化风险的预测因子）、打开和关闭特性以及瓣膜的密封质量。阀门。此外，还将开发新方法来减少计算时间。渥太华大学心脏研究所的一位主动脉瓣修复专家心脏外科医生以及一位训练有素的麻醉师和超声心动图医师承诺继续参与提供医疗专业知识和患者数据，从而最大限度地提高该研究项目的临床相关性。鉴于主动脉瓣修复相对于置换的临床和财务优势，这将极大有利于加拿大的医疗保健系统。