Control of Function and Reactivity in Lanthanide Chemistry by Tailored Ligand Design

通过定制配体设计控制镧系化学中的功能和反应性

基本信息

批准号：
RGPIN-2014-03707
负责人：
Berg, David
金额：
$ 2.48万
依托单位：
University of Victoria
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2014
资助国家：
加拿大
起止时间：
2014-01-01 至 2015-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=566044
关键词：
Control Function Reactivity Lanthanide Chemistry

项目摘要

The goal of the research described in this proposal is to control the physical and chemical properties of metal ions in compounds. Compounds of the lanthanide metals are the specific focus of this work because they offer important advantages over other metals including higher reactivity, different selectivity and desirable electronic and nuclear properties. Lanthanide chemistry has developed slowly because these metals require special coordination environments to form reactive compounds. In catalysis, for example, a fine balance must be achieved between formation of stable, isolable compounds and metal centres with sufficient reactivity to carry out useful chemical transformations. The new coordination systems described here are designed to achieve two very different purposes: (i) to allow the catalytic formation of C-C, C-N and other bonds in organic molecules and (ii) to form water and air stable lanthanide compounds that have pharmaceutical applications in medical imaging (magnetic resonance, gamma imaging, fluorescence imaging) or therapy (radio-lanthanide complexes as targeted anti-cancer drugs). Access to new organic molecules, facilitated by lanthanide catalysts, is critical to developing new pharmaceuticals and materials with unusual electronic, optical and magnetic properties. Lanthanide compounds have assumed a major role in medicine, acting as the pharmaceutical agent for imaging or targeted tumor destruction. The development of new coordination environments for the lanthanides that forms the basis of this proposal is critical to realizing the practical potential of these unique metals.

该提案中描述的研究目标是控制化合物中金属离子的物理和化学性质。镧系金属的化合物是这项工作的具体焦点，因为它们比其他金属具有重要的优势，包括更高的反应性、不同的选择性以及理想的电子和核性能。稀土化学发展缓慢，因为这些金属需要特殊的配位环境才能形成反应性化合物。例如，在催化中，必须在稳定、可分离的化合物的形成和具有足够反应性以进行有用的化学转化的金属中心之间实现良好的平衡。这里描述的新配位系统旨在实现两个截然不同的目的：(i) 允许在有机分子中催化形成 C-C、C-N 和其他键，以及 (ii) 形成在水和空气中稳定的镧系元素化合物，这些化合物在以下领域具有药物应用：医学成像（磁共振、伽马成像、荧光成像）或治疗（放射性镧系元素络合物作为靶向抗癌药物）。在稀土催化剂的促进下获得新的有机分子对于开发具有不寻常的电子、光学和磁性特性的新药物和材料至关重要。镧系元素化合物在医学中发挥着重要作用，充当成像或靶向肿瘤破坏的药剂。构成该提案基础的镧系元素新配位环境的开发对于实现这些独特金属的实际潜力至关重要。