The role of sleep oscillations in temporal lobe organization

睡眠振荡在颞叶组织中的作用

• 批准号: 356071-2008
• 负责人: Hoffman, Kari
• 金额: $ 2.18万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=483034
• 关键词: role; sleep; oscillations; temporal; lobe

Even when we sleep, the brain is not at rest. On the contrary, during sleep, the brain is full of synchronized neural activity that takes the shape of slow oscillations. These oscillations have long been associated with helping memories to strengthen, or 'consolidate', yet the brain regions involved during slow waves and the processing they undergo is still unresolved. Neurons in the neocortex that were active during an experience 'reactivate' during these sleep oscillations, suggesting one way of strengthening a memory trace. Although this phenomenon was first seen in the rat hippocampus - a structure that helps in forming new memories, I went on to show that reactivation occurs as a synchronized process throughout large, separated regions of the neocortex. This was also the first demonstration of memory trace reactivation in primates, an important prerequisite if reactivation underlies the consolidation of memories in humans.

即使我们入睡，大脑也不会休息。相反，在睡眠期间，大脑充满同步的神经活动，这种神经活动的形状慢慢振荡。这些振荡长期以来一直与帮助记忆加强或“巩固”有关，但是在慢速波浪中所涉及的大脑区域及其所进行的处理仍未解决。在这些睡眠振荡期间经历“重新激活”的新皮层中的神经元，这表明一种增强记忆痕迹的方法。尽管这种现象首先是在大鼠海马中出现的 - 一种有助于形成新记忆的结构，但我继续表明，重新激活是在新皮层的大型分离区域中作为同步过程发生的。这也是灵长类动物中记忆痕量重新激活的首次演示，如果重新激活是人类记忆的巩固，则是重要的先决条件。