Electrokinetic microfluidics

动电微流控

• 批准号: 155248-2009
• 负责人: Li, Dongqing
• 金额: $ 2.19万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=476015
• 关键词: Electrokinetic; microfluidics

A lab-on-a-chip (LOC) device is a microscale laboratory on a business-card-sized glass or plastic chip with a network of microchannels. Applying electrical fields along microchannels controls the liquid flow and other operations in the chip. These LOC devices can perform specialized functions as their room-sized counterparts, such as clinical diagnoses of bacteria infection and cancers. The key advantages include dramatically reduced sample and reagent consumption, high speed of analysis, automation and portability. Most biomedical analyses involve multiple biochemical and physical processes of molecules and cells in aqueous solutions. A LOC device therefore must integrate the functions of different bench-top instruments into a single chip, and can perform multiple, sequential microfluidic processes required for realizing the assays on a chip. In order to be able to systematically design LOC devices and control the chip operation precisely, one must understand the complicated microfluidic and nanofluidic phenomena and processes.

实验室芯片（LOC）设备是带有微通道网络的商务卡大小玻璃或塑料芯片上的微观实验室。沿微通道施加电场可控制芯片中的液体流量和其他操作。这些LOC设备可以执行专业功能作为其室大型对应物，例如细菌感染和癌症的临床诊断。关键优势包括大幅减少样品和试剂消耗，高速分析，自动化和便携性。大多数生物医学分析都涉及水溶液中分子和细胞的多种生化和物理过程。 因此，LOC设备必须将不同的基准仪器的功能集成到单个芯片中，并且可以执行在芯片上实现测定所需的多个顺序的微流体过程。 为了能够系统地设计LOC设备并精确地控制芯片操作，必须了解复杂的微流体和纳米流体现象和过程。