Electrokinetic Phenomena in Microfluidics and Nanofluidics
微流体和纳流体中的动电现象
基本信息
- 批准号:RGPIN-2021-02411
- 负责人:
- 金额:$ 3.35万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The proposed research program is to investigate several new electrokinetic microfluidic phenomena critical to the development of lab-on-a-chip devices for applications in medical diagnosis and food safety, including: (1) Electroosmotic flow and electrophoresis of water-immiscible ionic liquids (IL). Because of the high viscosity of ILs, it is necessary to transport ionic liquids in microchannels by electrokinetic means, i.e., electroosmotic flow and electrophoresis. However, there are no any reported works in this regard. Therefore, it is necessary to conduct systematic research to understand the electroosmotic flow of ionic liquids and electrophoretic motion of ionic liquid droplets in microchannels. The expected results of the proposed research will provide not only scientific insight but also the valuable experimental data of electroosmotic flow of ionic liquids and electrophoretic motion of ionic liquid droplets, for future development of microfluidic lab-on-chip technology by using ionic liquids. (2) Electrokinetic phenomena of Janus droplets made by immiscible ionic liquids. In this research, we propose to develop a novel category of ionic liquid Janus droplets by using two immiscible ionic liquids in microfluidic chips, and study electrokinetic transport phenomena of ionic liquid Janus droplets in microchannels. We will investigate (A) How to control the size of the Janus droplets and the proportion of the Janus droplet occupied by one of the two ionic liquids. (B) The electrophoretic mobility of ionic liquid droplets. (C) The velocity of the electrokinetic motion of the Janus droplets as a function of the applied electric field and the proportion of the two immiscible ionic liquids. (D) How to separate the Janus droplets by size and by the proportion of the two immiscible ionic liquids in microfluidic chips. (3) EOF of nanochannels modified with charged polyelectrolyte layers. In order to modulate electrokinetic transport of electrolyte solutions in small nanochannels, this research will examine how to control the surface charge of the channel wall and the cross-section size of nanochannels by using layer-by-layer surface coating of Polybrene (PB) and Dextran sulfate (DS). PB has positive surface charge and DS has negative surface charge and they can be coated on the PDMS surface alternatively (i.e., one positively charged PB layer followed by a negatively charged DS layer, and so on). We will investigate the controlling factors of building multiple coated layers and surface charges of the modified nanochannels, and the effects of these factors on the electroosmotic flow in small nanochannels. We will examine (A) the effects of ionic concentration of the electrolyte solution. (B) the effects of ion size of the electrolytes. (C) the electroosmotic flow (EOF) velocity which will be measured in the modified nanochannels with different numbers of the coated layers by using the current-slope method.
拟议的研究计划旨在研究几种新的电动微流体现象,这对于用于医学诊断和食品安全中应用的实验室芯片设备至关重要,包括:(1)电流流动流和水不混杂的离子液体(IL)的电泳。由于IL的粘度很高,因此有必要通过电动均值(即电流流量和电泳)在微通道中运输离子液体。但是,在这方面没有任何报告的作品。因此,有必要进行系统研究以了解微通道中离子液体的电流流量和离子液滴的电泳运动。拟议的研究的预期结果不仅将提供科学见解,还将提供离子液体电流流和电泳运动的有价值的实验数据,用于使用离子液体的微流体实验室技术的未来开发。 (2)由不混溶的离子液体制成的Janus液滴的电动现象。在这项研究中,我们建议通过在微流体芯片中使用两个不混溶的离子液体来开发一种新型的离子液体Janus液滴,并研究微通道中离子液体Janus液滴的电动传输现象。我们将研究(a)如何控制janus液滴的大小以及两种离子液体之一占据的Janus液滴的比例。 (b)离子液滴的电泳迁移率。 (c)Janus液滴的电动运动的速度是施加的电场的函数以及两个不混溶的离子液体的比例。 (d)如何按大小和微流体芯片中两个不混溶的离子液体的比例分离janus液滴。 (3)用带电的聚电解质层修饰的纳米通道的EOF。为了调节小纳米通道中电解质溶液的电动传输,这项研究将研究如何使用多脑烯(PB)和硫酸右甲烯(DS)的一层表面涂层来控制通道壁的表面电荷和纳米波道的横截面大小。 PB具有正表电荷,DS的表面电荷为负,并且可以涂在PDMS表面上(即,一个带正电荷的PB层,然后是带负电荷的DS层,依此类推)。我们将研究修饰的纳米通道的多个涂层层和表面电荷的控制因子,以及这些因素对小纳米渠道中电流流的影响。我们将检查(a)电解质溶液的离子浓度的影响。 (b)电解质的离子大小的影响。 (c)通过使用电流斜率方法,将在具有不同数量的涂层层的修饰纳米通道中测量的电流流(EOF)速度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Li, Dongqing其他文献
Micro-valve using induced-charge electrokinetic motion of Janus particle
- DOI:
10.1039/c1lc20229d - 发表时间:
2011-01-01 - 期刊:
- 影响因子:6.1
- 作者:
Daghighi, Yasaman;Li, Dongqing - 通讯作者:
Li, Dongqing
miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
- DOI:
10.1016/j.jid.2020.06.037 - 发表时间:
2021-02-19 - 期刊:
- 影响因子:6.5
- 作者:
Li, Dongqing;Peng, Hongmei;Landen, Ning Xu - 通讯作者:
Landen, Ning Xu
High-throughput and sensitive particle counting by a novel microfluidic differential resistive pulse sensor with multidetecting channels and a common reference channel
- DOI:
10.1002/elps.201400427 - 发表时间:
2015-02-01 - 期刊:
- 影响因子:2.9
- 作者:
Song, Yongxin;Yangi, Jiandong;Li, Dongqing - 通讯作者:
Li, Dongqing
Thermodynamic analysis of electrokinetic energy conversion
- DOI:
10.1016/j.jpowsour.2005.05.057 - 发表时间:
2006-06-01 - 期刊:
- 影响因子:9.2
- 作者:
Xuan, Xiangchun;Li, Dongqing - 通讯作者:
Li, Dongqing
Detection of activity of single microalgae cells in a new microfluidic cell capturing chip
新型微流控细胞捕获芯片中单个微藻细胞活性检测
- DOI:
10.1088/0957-0233/27/12/125701 - 发表时间:
2016-10 - 期刊:
- 影响因子:2.4
- 作者:
Meng, Xiongfei;Song, Yongxin;Pan, Xinxiang;Li, Dongqing - 通讯作者:
Li, Dongqing
Li, Dongqing的其他文献
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{{ truncateString('Li, Dongqing', 18)}}的其他基金
Electrokinetic Phenomena in Microfluidics and Nanofluidics
微流体和纳流体中的动电现象
- 批准号:
RGPIN-2021-02411 - 财政年份:2022
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic Microfluidics
动电微流控
- 批准号:
RGPIN-2016-03622 - 财政年份:2020
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic Microfluidics
动电微流控
- 批准号:
RGPIN-2016-03622 - 财政年份:2019
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic Microfluidics
动电微流控
- 批准号:
RGPIN-2016-03622 - 财政年份:2018
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic Microfluidics
动电微流控
- 批准号:
RGPIN-2016-03622 - 财政年份:2017
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic Microfluidics
动电微流控
- 批准号:
RGPIN-2016-03622 - 财政年份:2016
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic microfluidics
动电微流控
- 批准号:
155248-2009 - 财政年份:2013
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Electrokinetic microfluidics
动电微流控
- 批准号:
155248-2009 - 财政年份:2012
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Canada Research Chair in Microfluidics and Nanofluidics
加拿大微流控和纳流控研究主席
- 批准号:
1000209322-2008 - 财政年份:2012
- 资助金额:
$ 3.35万 - 项目类别:
Canada Research Chairs
Electrokinetic microfluidics
动电微流控
- 批准号:
155248-2009 - 财政年份:2011
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
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