Venoms to drugs: translating venom peptides into therapeutics

毒液到药物：将毒液肽转化为治疗药物

• 批准号: nhmrc : 1044414
• 负责人: Prof Glenn King
• 金额: $ 50.13万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/venoms-drugs-translating-peptides-therapeutics/111661
• 关键词: Venoms; drugs; translating; venom; peptides

Chronic pain is a major global health problem that currently affects over three million Australians. There are few drugs available for treating chronic pain and many have significant side-effects. Several ion channels are critical for conducting pain signals to the brain. Blocking these channels can provide pain relief and, in some cases, protection from brain injury following stroke. We are producing potent and selective blockers of these ion channels for the treatment of chronic pain and stroke.

慢性疼痛是一个主要的全球健康问题，目前影响超过300万澳大利亚人。很少有药物可用于治疗慢性疼痛，许多药物具有明显的副作用。几个离子通道对于向大脑进行疼痛信号至关重要。阻止这些通道可以减轻疼痛，在某些情况下，可以防止中风后脑损伤。我们正在生产这些离子通道的有效阻滞剂，以治疗慢性疼痛和中风。