Unravelling the molecular diversity and evolution of centipede venoms

揭示蜈蚣毒液的分子多样性和进化

• 批准号: DP160104025
• 负责人: Prof Glenn King
• 金额: $ 22.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104025
• 关键词: Unravelling; molecular; diversity; evolution; centipede

The project intends to improve understanding of venom evolution in centipedes. Venoms have emerged as a rich source of pharmacological tools with potential for development into therapeutics and bioinsecticides. However, venoms-based discovery has been limited by the narrow taxonomical range of animals studied, with many groups of venomous animals overlooked. One such group is centipedes, whose venoms contain diverse toxins that differ between taxa. This project aims to provide an insight into centipede venom evolution, and how it might be constrained by venom-gland morphology. This study seeks to contribute to our understanding of protein evolution and direct biodiscovery efforts around centipede venom.

该项目旨在提高对cente的毒液进化的理解。毒液已成为丰富的药理学工具来源，具有开发到治疗剂和生物剂剂的潜力。但是，基于毒液的发现受到研究的狭窄分类范围的限制，许多有毒动物被忽略了。一个这样的群体是cente，其毒液中包含不同的毒素在分类单元之间有所不同。该项目旨在提供对毒液演化的洞察力，以及如何通过毒液形态来限制它。这项研究旨在为我们理解蛋白质进化和围绕毒液的直接生物发现努力做出贡献。