Gain from pain: new tools from venomous animals for exploring pain pathways

从痛苦中获益：有毒动物探索疼痛途径的新工具

• 批准号: DP190103787
• 负责人: Prof Glenn King
• 金额: $ 28.43万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2022-01-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103787
• 关键词: Gain; pain; new; tools; venomous

This project aims to explore animal venoms for new pain-causing toxins, to determine their structure and mechanism of action. Many venomous animals use their venom defensively and envenomation is frequently associated with rapid and often excruciating pain. In most cases the molecular mechanisms by which they achieve this is unknown. Using biochemical, pharmacological and biophysical techniques, this project expects to uncover toxins that employ new mechanisms of pain signalling, leading to new insights into pain physiology.

该项目旨在探索动物毒液的新型止痛毒素，以确定其作用的结构和机理。许多有毒动物在防御性上使用毒液，并且蛋白质经常与快速且经常令人难以置信的疼痛有关。在大多数情况下，实现这一目标的分子机制是未知的。该项目使用生化，药理学和生物物理技术，希望发现采用新的疼痛信号传导机制的毒素，从而导致对疼痛生理学的新见解。