Understanding the assembly of the Commander complex.

了解指挥官复合体的组装。

• 批准号: nhmrc : GNT1156732
• 金额: $ 70.44万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-assembly-commander-complex/1378955
• 关键词: Understanding; assembly; Commander; complex.

Controlling the synthesis, recycling and degradation of receptors in the cell is absolutely essential for normal cellular function, regulating processes as diverse as the metabolism and synaptic communication. This project we will determine how Commander, a protein machine that controls retrieval, export and recycling of receptors is assembled as a large multi subunit assembly. This will provide insights into how Commander regulates complex pathways of cellular homeostasis in health and disease.

控制细胞中受体的合成、回收和降解对于正常细胞功能、调节新陈代谢和突触通讯等多种过程绝对至关重要。在这个项目中，我们将确定 Commander（一种控制受体的检索、输出和回收的蛋白质机器）如何组装为大型多亚基组件。这将为了解 Commander 如何调节健康和疾病中细胞稳态的复杂途径提供见解。