Structural Studies on Human Glutamic Acid Decarboxylase

人谷氨酸脱羧酶的结构研究

• 批准号: nhmrc : 1064612
• 负责人: Dr Ruby Law
• 金额: $ 25.4万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-studies-human-acid-decarboxylase/455129
• 关键词: Structural; Studies; Human; Glutamic; Acid

Mental health problems are a global issue and are subject to ongoing medical research. We study glutamic acid decarboxylase, a key enzyme responsible for the synthesis of a prominent and abundant neurotransmitter called GABA. GABA is crucial in controlling neuronal responses and facilitating new interconnections between neurones. Lacking GABA is related to epilepsy, Parkinson's disease, and post-traumatic stress. Our study is important for development of new ways to improve the supply of GABA in the brain.

心理健康问题是一个全球性问题，并且受到持续医学研究的影响。我们研究谷氨酸脱羧酶，这是一种关键酶，负责合成一种重要且丰富的神经递质 GABA。 GABA 对于控制神经元反应和促进神经元之间新的互连至关重要。缺乏 GABA 与癫痫、帕金森病和创伤后应激障碍有关。我们的研究对于开发改善大脑中 GABA 供应的新方法非常重要。