Activation and inhibition of the Plasminogen/Plasmin system

纤溶酶原/纤溶酶系统的激活和抑制

• 批准号: nhmrc : GNT1127593
• 负责人: Dr Ruby Law
• 金额: $ 80.07万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activation-inhibition-plasminogenplasmin/1347633
• 关键词: Activation; inhibition; Plasminogen; Plasmin; system

Plasmin is crucial enzyme present in blood plasma that functions in clot dissolution, inflammation, tissue remodeling, and wound healing. We aim to study how this enzyme system is controlled, by studying its interaction with receptors, co-factors and inhibitors. The information we gain will help drive the development of new generation therapeutics for the fine control of plasmin function in clotting disease, bleeding and inflammation.

纤溶酶是血浆中存在的关键酶，在凝块溶解、炎症、组织重塑和伤口愈合中发挥作用。我们的目标是通过研究该酶系统与受体、辅助因子和抑制剂的相互作用来研究该酶系统是如何被控制的。我们获得的信息将有助于推动新一代疗法的开发，以精细控制凝血疾病、出血和炎症中纤溶酶的功能。