A signalling endosomal network in T cell activation

T 细胞激活中的信号传导内体网络

• 批准号: nhmrc : 1102730
• 负责人: Dr Jeremie Rossy
• 金额: $ 29.35万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signalling-endosomal-network-cell-activation/662628
• 关键词: signalling; endosomal; network; cell; activation

T lymphocytes play a central role in the adaptive immune response, which specifically targets pathogens and cancer cells and creates the immunological memory. Activation of sometimes as little as one single receptor on a T cell triggers a cellular signal that rapidly expands and branches out in a multitude of sub-signals. Here we will use a combination of novel microscopy approaches to visualise how a network of dedicated intracellular compartments is in charge of these processes.

T 淋巴细胞在适应性免疫反应中发挥核心作用，该反应专门针对病原体和癌细胞并创建免疫记忆。有时，T 细胞上哪怕只有一个受体的激活也会触发细胞信号，该信号会迅速扩展并分支为多个子信号。在这里，我们将结合使用新颖的显微镜方法来可视化专用细胞内区室网络如何负责这些过程。