Regulation of the signalling efficiency of the T cell antigen receptor

T 细胞抗原受体信号传导效率的调节

• 批准号: nhmrc : 1129609
• 负责人: Dr Jeremie Rossy
• 金额: $ 31.15万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-signalling-efficiency-antigen-receptor/948418
• 关键词: Regulation; signalling; efficiency; cell; antigen

An immune response starts with activation of the T cell antigen receptor (TCR). How T cell receptor signalling begins, however, is not well understood. We have developed a novel imaging approach that allows us to directly observe what happens after an antigen binds to the receptor. The research will provide mechanistic insights into how T cells sense and discriminate antigens. This knowledge will aid the development of cancer immunotherapies and vaccines.

免疫反应始于 T 细胞抗原受体 (TCR) 的激活。然而，T 细胞受体信号传导是如何开始的尚不清楚。我们开发了一种新颖的成像方法，使我们能够直接观察抗原与受体结合后发生的情况。该研究将为 T 细胞如何感知和区分抗原提供机制见解。这些知识将有助于癌症免疫疗法和疫苗的开发。