Regulation of cell death, cell survival and ubiquitination in normal physiology and disease

正常生理和疾病中细胞死亡、细胞存活和泛素化的调节

• 批准号: nhmrc : GNT1103006
• 负责人: Prof Sharad Kumar
• 金额: $ 85.2万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-cell-death-physiology-disease/1346256
• 关键词: Regulation; cell; death; survival; ubiquitination

The project will investigate the functions of specific genes and pathways to understand the molecular basis of various diseases. It is based on our data that indicate new roles for (i) cell death in genomic instability in cancer, and (ii) ubiquitination in hypertension, developmental defects, kidney disease, as well as iron homeostasis. The work will lead to new understanding of human disease and discovery of potential new drug targets. It will also provide training of junior scientists.

该项目将研究特定基因和通路的功能，以了解各种疾病的分子基础。它基于我们的数据，表明（i）细胞死亡在癌症基因组不稳定性中的新作用，以及（ii）泛素化在高血压、发育缺陷、肾脏疾病以及铁稳态中的新作用。这项工作将带来对人类疾病的新认识并发现潜在的新药物靶点。它还将为初级科学家提供培训。