Characterisation of the tumour suppressor function of caspase-2

Caspase-2 肿瘤抑制功能的表征

• 批准号: nhmrc : 626905
• 负责人: Prof Sharad Kumar
• 金额: $ 40.35万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-tumour-suppressor-caspase-2/101457
• 关键词: Characterisation; tumour; suppressor; function; caspase

Aberrant cell death (apoptosis) is associated with many diseases including cancer. Apoptosis is mediated by a group of enzymes called caspases. Recently we have discovered that one of these enzymes, caspase-2, acts as a tumour suppressor. We now wish to validate this finding in several preclinical models of cancer and understand precisely how caspase-2 works to safeguard cells against cancer development. These studies will help better understand cancer and ways to treat it.

异常细胞死亡（细胞凋亡）与包括癌症在内的许多疾病有关。细胞凋亡是由一组称为半胱天冬酶的酶介导的。最近我们发现其中一种酶，caspase-2，可以起到肿瘤抑制因子的作用。我们现在希望在几种癌症临床前模型中验证这一发现，并准确了解 caspase-2 如何保护细胞免受癌症发展。这些研究将有助于更好地了解癌症及其治疗方法。