Characterisation of two new kinases in the Hippo tumour suppressor pathway

Hippo 肿瘤抑制通路中两种新激酶的表征

• 批准号: nhmrc : 1060090
• 负责人: Prof Kieran Harvey
• 金额: $ 36.71万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-new-kinases-suppressor-pathway/454800
• 关键词: Characterisation; two; new; kinases; Hippo

The Hippo pathway is a key regulator of tissue growth. It was first discovered in vinegar flies and plays a similar role in mammals. We aim to define the mechanism by which the Gish and Fray kinases control tissue growth by regulating the Hippo pathway. These studies will be performed in flies and mammalian cell culture. Our studies will shed light on how tissue growth is controlled, and have the potential to inform the way that we treat human cancers and tissue growth disorders.

Hippo 通路是组织生长的关键调节因子。它首先在醋蝇中发现，并在哺乳动物中发挥类似的作用。我们的目标是确定 Gish 和 Fray 激酶通过调节 Hippo 通路来控制组织生长的机制。这些研究将在果蝇和哺乳动物细胞培养物中进行。我们的研究将揭示如何控制组织生长，并有可能为我们治疗人类癌症和组织生长障碍的方式提供信息。