How neurons maintain their fate

神经元如何维持其命运

• 批准号: DP190101743
• 负责人: Prof Kieran Harvey
• 金额: $ 31.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-17 至 2022-06-16
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101743
• 关键词: How; neurons; maintain; their; fate

This project aims to investigate how neurons maintain their identity, without reverting back to less specialised cells. Stable fate maintenance is essential because when it fails, cells lose their ability to perform their ascribed function, which impedes organism fitness. This project aims to define how two proteins work in partnership to maintain the identity of brain neurons. We intend our discoveries to stimulate new research, for example to test whether the human counterparts of the Drosophila proteins studied here, function similarly. Benefits will be provided in the form of job creation, and new knowledge in fundamental aspects of life, including brain development and cell fate maintenance.

该项目旨在研究神经元如何保持其身份，而不恢复为不太特化的细胞。稳定的命运维持至关重要，因为当它失败时，细胞就会失去执行其固有功能的能力，从而阻碍有机体的健康。该项目旨在定义两种蛋白质如何协同工作以维持大脑神经元的身份。我们希望我们的发现能够激发新的研究，例如测试此处研究的果蝇蛋白质的人类对应物是否具有相似的功能。福利将以创造就业机会和生活基本方面的新知识的形式提供，包括大脑发育和细胞命运维持。