A novel mechanism for regulating membrane proteins by ubiquitin ligases and their adaptors

通过泛素连接酶及其接头调节膜蛋白的新机制

• 批准号: nhmrc : 1059393
• 负责人: Prof Sharad Kumar
• 金额: $ 41.87万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-mechanism-regulating-ligases-adaptors/454753
• 关键词: novel; mechanism; regulating; membrane; proteins

Many membrane proteins act as ion channels, transporters or receptors for extracellular ligands and are critical to normal functioning of the cell. These proteins are generally regulated by transport to or from the membrane to ensure that correct levels are maintained at the membrane. This proposal is to study a novel way of regulating membrane proteins. The successful completion of the work will provide important knowledge relevant to many human diseases.

许多膜蛋白充当细胞外配体的离子通道、转运蛋白或受体，对细胞的正常功能至关重要。这些蛋白质通常通过进出膜的运输来调节，以确保在膜上维持正确的水平。该提案旨在研究一种调节膜蛋白的新方法。这项工作的成功完成将为许多人类疾病提供重要的知识。