The transcriptional control of lymphatic vessel development.

淋巴管发育的转录控制。

• 批准号: FT130101254
• 负责人: Prof Natasha Harvey
• 金额: $ 60.87万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-03-05 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130101254
• 关键词: transcriptional; control; lymphatic; vessel; development.

Lymphatic vessels are a vital, but often overlooked, component of the cardiovascular system. These specialised vessels return tissue fluid to the bloodstream, absorb dietary lipids and transport cells of the immune system throughout the body. Defects in the growth and development of lymphatic vessels result in disorders including lymphedema, obesity, inflammatory diseases and cancer. This project aims to define how transcription factors program lymphatic vessel identity and control the development of lymphatic vessel valves. This knowledge will provide new insight into the fundamental mechanisms by which the lymphatic vasculature is constructed during development.

淋巴管是心血管系统的重要组成部分，但经常被忽视。这些专门的血管将组织液返回血液，吸收膳食脂质并将免疫系统细胞运输到全身。淋巴管生长和发育的缺陷会导致淋巴水肿、肥胖、炎症性疾病和癌症等疾病。该项目旨在定义转录因子如何编程淋巴管特性并控制淋巴管瓣膜的发育。这些知识将为了解发育过程中淋巴管系统构建的基本机制提供新的见解。