Defining how cells relay mechanical signals to changes in cell architecture

定义细胞如何将机械信号传递给细胞结构的变化

• 批准号: DP240103259
• 负责人: Prof Natasha Harvey
• 金额: $ 65.54万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103259
• 关键词: Defining; how; cells; relay; mechanical

Mechanical signals play crucial roles in shaping organs and entire organisms during development, though how these signals are relayed to changes in cell architecture is a major unanswered question. Within vascular networks, mechanical signals including fluid flow, tension and stretch play key roles in vessel patterning, identity and maturation. This application aims to employ cutting-edge technologies to determine how the atypical cadherin FAT4 relays mechanical signals including flow and tension to the lymphatic endothelial cell skeleton, thereby enabling changes in cell shape important for building lymphatic vessels. This project will increase our understanding of how cells sense touch and may be applied for tissue engineering purposes.

机械信号在发育过程中塑造器官和整个生物体方面发挥着至关重要的作用，尽管这些信号如何传递到细胞结构的变化是一个尚未解答的主要问题。在血管网络内，包括流体流动、张力和拉伸在内的机械信号在血管模式、身份和成熟中发挥着关键作用。该应用旨在采用尖端技术来确定非典型钙粘蛋白 FAT4 如何将机械信号（包括流量和张力）传递到淋巴管内皮细胞骨架，从而实现对构建淋巴管至关重要的细胞形状的变化。该项目将增进我们对细胞如何感知触觉的理解，并可应用于组织工程目的。