Defining how molecular switches program cell identity during development

定义分子开关在发育过程中如何编程细胞身份

• 批准号: DP210103351
• 负责人: Prof Natasha Harvey
• 金额: $ 43.14万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103351
• 关键词: Defining; how; molecular; switches; program

Aims: This project aims to investigate how molecular switches known as transcription factors, work together to turn genes on or off to program cell identity during development. Significance: This project expects to generate new knowledge in the area of genetics and developmental biology using collaborative, cutting edge technologies. Outcomes: Expected outcomes of this project include the identification of new genes important for programming the identity of cells that comprise our blood vessels, lymphatic vessels and circulating blood cells. Benefits: Data generated will underpin the development of approaches to program/reprogram stem cells to produce mature cells for transplantation or tissue engineering purposes ex vivo.

目的：该项目旨在研究被称为转录因子的分子开关如何协同工作来打开或关闭基因，从而在发育过程中编程细胞身份。 意义：该项目期望利用协作的尖端技术产生遗传学和发育生物学领域的新知识。 成果：该项目的预期成果包括识别对构成血管、淋巴管和循环血细胞的细胞身份进行编程重要的新基因。 好处：生成的数据将支持对干细胞进行编程/重编程的方法的开发，以产生用于离体移植或组织工程目的的成熟细胞。