INSULIN RESISTANCE PREDICTS ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR RISK

胰岛素抵抗可预测内皮功能障碍和心血管风险

• 批准号: 8168757
• 负责人: KRISTIN E. MONDY
• 金额: $ 1.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168757
• 关键词: Address; Adult; Age; Blood Vessels; Body mass index; Clinical; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Cross-Sectional Studies; Dual-Energy X-Ray Absorptiometry; Fasting; Functional disorder; Funding; Grant; HIV; Highly Active Antiretroviral Therapy; Institution; Insulin; Insulin Resistance; Lipids; Mediating; Metabolic; OGTT; Persons; Race; Research; Research Personnel; Resources; Source; Testing; Thick; Ultrasonography; United States National Institutes of Health; Vasodilation; brachial artery; cardiovascular disorder risk; cardiovascular risk factor; design; intima media; prospective; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: Cardiovascular disease risk among persons with HIV is likely multifactorial, thus testing a variety of available noninvasive vascular ultrasound and other surrogate tests may yield differing results. To address this issue, we assessed multiple metabolic and clinical predictors of endothelial function and carotid intima-media thickness in HIV-infected subjects and compared results with HIV-negative controls. DESIGN: Prospective, cross-sectional study of 50 HIV-infected, healthy adults on stable highly active antiretroviral therapy matched to 50 HIV-negative controls by age, sex, race, and body mass index. METHODS: Flow-mediated vasodilation of the brachial artery, carotid intima-media thickness, dual energy X-ray absorptiometry (HIV-infected subjects), and fasting insulin, lipids, and oral glucose tolerance tests were performed. Results were compared between HIV-infected and control groups.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：艾滋病毒感染者的心血管疾病风险可能是多因素的，因此测试各种可用的无创血管超声和其他替代测试可能会产生不同的结果。为了解决这个问题，我们评估了 HIV 感染者的内皮功能和颈动脉内膜中层厚度的多种代谢和临床预测因子，并将结果与​​ HIV 阴性对照进行了比较。设计：对 50 名接受稳定高效抗逆转录病毒治疗的 HIV 感染健康成年人进行前瞻性横断面研究，并与 50 名按年龄、性别、种族和体重指数进行匹配的 HIV 阴性对照进行研究。方法：进行肱动脉血流介导的血管舒张、颈动脉内膜中层厚度、双能X射线吸收测定法（HIV感染者）以及空腹胰岛素、血脂和口服葡萄糖耐量试验。对艾滋病毒感染者组和对照组的结果进行了比较。