Organ Design and Engineering Training Program (ODET Program)

器官设计与工程培训项目（ODET项目）

• 批准号: 9096101
• 负责人: JOSEPH VINCENT BONVENTRE
• 金额: $ 34.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096101
• 关键词: Organ; Training Programs; engineering design

DESCRIPTION (provided by applicant): The number of available organs is severely limited by a shortage of donors. A new field of science, regenerative medicine, has emerged that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. T develop functional tissue requires applying concepts in developmental biology, quantitative science and tissue engineering approaches in a novel way. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and other disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training to postdoctoral fellows at Harvard and MIT. Individuals accepted into the Program are cross-trained in an area of expertise outside of their primary research field. This is a continuation of an ARRA-funded training program, reduced in size. Working at the intersection of engineering and developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program mentoring and a required course. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true ["dual-mentor" model where fellows spend time in the laboratories of two mentors and are able to facilitate active communication across laboratories, institutions and geographic boundaries.] This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 5 years have high quality publications, have moved to academic faculty, international research lab and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.

描述（由申请人提供）：由于捐赠者短缺，可用器官的数量受到严重限制。再生医学这一新的科学领域的出现，使设计和制造人造器官或器官部分的潜力更接近现实。开发功能性组织需要以新颖的方式应用发育生物学、定量科学和组织工程方法中的概念。这需要一种新型科学家，他们在工程和其他学科交叉的概念和方法方面接受过良好的培训。成功整合这些方法可以极大地促进新的跨学科器官构建方法的形成。这将对许多疾病的治疗产生深远的影响。 ODET（器官设计与工程博士后培训）计划继续为哈佛大学和麻省理工学院的博士后提供科学严谨的多学科研究培训。接受该计划的个人在其主要研究领域之外的专业领域接受交叉培训。这是 ARRA 资助的培训计划的延续，但规模有所缩小。在工程和发育/再生生物学的交叉领域工作，学员学习一门新语言，并最终开发出一种有效连接学科的通用方言。新一代学者准备通过跨学科的方法来解决器官设计和工程的复杂性。该项目拥有出色的双导师互动、定期安排的项目指导和必修课程。 自 2007 年启动以来，该计划已正式对学员的发展进行评估，并提供了更多的研究展示和反馈机会。我们成功地将标准的博士后培养模式从“一名博士后-一名导师-一个实验室”的方式转变为真正的“双导师”模式，即研究员在两位导师的实验室里呆着，能够促进积极的沟通跨实验室、机构和地理边界。] 该计划继续为学员提供成为易于采用跨学科科学方法的独立研究人员所需的工具。过去 5 年获得此项资助的学员发表了高质量的论文，并晋升到学术教师、国际研究实验室和行业领导职位。我们期待继续培训接触临床挑战的多学科研究领导者，同时通过优化再生医学领域下一代工程师研究员的研究和指导机会，批判性地评估和改善奖学金体验。