Organ Design and Engineering Training Program (ODET Program)

器官设计与工程培训项目（ODET项目）

• 批准号: 10681212
• 负责人: JOSEPH VINCENT BONVENTRE
• 金额: $ 41.08万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681212
• 关键词: Engineering; Organ; Training Programs; design

The number of available organs for transplantation is severely limited by a shortage of donors. Regenerative medicine has emerged as a field that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. To develop functional tissue requires applying concepts in tissue engineering and molecular/developmental biology in innovative ways. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and the molecular/developmental biology disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training for postdoctoral fellows. Individuals accepted into the Program have experience focused in an engineering or biological discipline and are cross-trained in an area of expertise complementary to their primary research background. Working at the intersection of engineering and molecular/developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program meetings, where fellows and faculty cross-fertilize, and required coursework focused on biological science if fellows are engineers and engineering if their prior focus was in biology. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true “dual-mentor” model where fellows spend time in the laboratories of two mentors and benefit from active communication across laboratories, institutions and geographic boundaries. This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 10 years have high quality publications, have moved to academic faculty, international research labs and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges facilitated by close interactions with clinicians, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.

由于供体短缺，可供移植的器官数量受到严重限制。 再生医学已经成为一个带来设计和创造人工潜力的领域 器官或器官的一部分，更接近现实，需要应用概念。 以创新的方式进行组织工程和分子/发育生物学，这需要一种新型的方法。 受过良好训练的科学家，其概念和方法涉及工程学和自然科学的交叉点 分子/发育生物学学科的成功整合可以。 极大地促进了新的跨学科器官构建方法的形成。 对许多疾病的治疗产生深远的影响。 ODET（器官设计与工程博士后培训）计划继续提供 接受对博士后研究员进行科学严谨的多学科研究培训。 加入该计划的人具有工程或生物学科的经验，并接受过交叉培训 在与他们的主要研究背景互补的专业领域。 工程和分子/发育/再生生物学的学员学习一门新的语言 最终开发出一种有效的通用方言来连接新一代的学科。 学者们准备从跨学科的角度解决器官设计和工程的复杂性 该计划通过定期安排的出色的双导师互动来丰富。 项目会议，研究员和教师相互交流，所需的课程集中于 如果研究员是工程师，则为生物科学；如果他们之前的关注点是生物学，则为工程学。 自2007年启动以来，该计划已将学员的发展评估正式化为 并提供了更多的研究演示和反馈的机会，我们成功了。 改变了博士后标准培养模式，由“一名博士后-一名导师-一名” 实验室”方法，以实现真正的“双导师”模式，其中研究员花时间在两个实验室 导师并从跨实验室、机构和地理区域的积极沟通中受益 该计划继续为学员提供独立所需的工具。 研究人员协助接受支持的受训者采用跨学科的科学方法。 从这笔拨款中，过去10年有高质量的出版物，已转移到学术教职人员， 我们期待继续培训国际研究实验室和行业领导职位。 多学科研究的领导者，通过密切的互动接触临床挑战 与圣人一起，同时通过优化研究批判性地评估和改善团契体验 并为下一代再生医学工程师研究人员提供指导机会。

项目成果

Closed loop bioreactor system for the ex vivo expansion of human T cells.

用于人类 T 细胞离体扩增的闭环生物反应器系统。

• 发表时间: 2019
• 影响因子: 4.5
• 作者: Li, Matthew;Chin, Ling;Shukor, Syukri;Tamayo, Alfred;Maus, Marcela V;Parekkadan, Biju
• 通讯作者: Parekkadan, Biju

SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome.

SARS-CoV-2 RNA 逆转录并整合到人类基因组中。

• 发表时间: 2020-12-13
• 作者: Zhang, Liguo;Richards, Alexsia;Khalil, Andrew;Wogram, Emile;Ma, Haiting;Young, Richard A;Jaenisch, Rudolf
• 通讯作者: Jaenisch, Rudolf

Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration.

用于基于干细胞的组织工程和再生的富含血小板的血液衍生物。

• 发表时间: 2016-03
• 影响因子: 1.4
• 作者: Masoudi, Elham;Ribas, João;Kaushik, Gaurav;Leijten, Jeroen;Khademhosseini, Ali
• 通讯作者: Khademhosseini, Ali

Local microRNA delivery targets Palladin and prevents metastatic breast cancer.

局部 microRNA 递送靶向 Palladin 并预防转移性乳腺癌。

• 发表时间: 2016
• 影响因子: 16.6
• 作者: Gilam, Avital;Conde, João;Weissglas;Oliva, Nuria;Friedman, Eitan;Artzi, Natalie;Shomron, Noam
• 通讯作者: Shomron, Noam

Matrix degradability controls multicellularity of 3D cell migration.

基质降解性控制 3D 细胞迁移的多细胞性。

• 发表时间: 2017-08-29
• 影响因子: 16.6
• 作者: Trappmann, Britta;Baker, Brendon M;Polacheck, William J;Choi, Colin K;Burdick, Jason A;Chen, Christopher S
• 通讯作者: Chen, Christopher S