Volumetric Real-Time MRI at 0.55 Tesla

0.55 特斯拉的体积实时 MRI

• 批准号: 10611241
• 负责人: Adrienne Campbell
• 金额: $ 52.56万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611241
• 关键词: 3-Dimensional; 3D ultrasound; Adult; Air; Anatomy; Arrhythmia; Basic Science; Breathing; Cardiac; Cardiac Catheterization Procedures; Cardiac Output; Cardiac ablation; Cardiovascular system; Caring; Catheterization; Catheters; Clinical; Collaborations; Data; Deposition; Detection; Development; Devices; Diagnostic Imaging; Disease; Disease Progression; Early Diagnosis; Engineering; Evaluation; Extramural Activities; Goals; Heart; Heating; Image; Imaging technology; Intervention; Ionizing radiation; Magnetic Resonance Imaging; Manuals; Methods; Modality; Monitor; Morphologic artifacts; Motion; Movement; Myocardial; National Heart, Lung, and Blood Institute; Obstructive Sleep Apnea; Organ; Outcome; Patient Care; Patients; Pattern; Performance; Physiologic pulse; Procedures; Relapsing polychondritis; Relaxation; Research; Resolution; Sampling; Scanning; Scientist; Sleep Apnea Syndromes; Slice; Surface; System; Techniques; Technology; Testing; Time; Tissues; Trachea; Training; Translating; Ultrasonography; United States National Institutes of Health; Variant; Visualization; Work; X-Ray Computed Tomography; clinical center; clinical translation; cohort; data acquisition; deep learning; flexibility; heart function; heart imaging; image reconstruction; imaging approach; imaging modality; improved; innovation; instrument; lung imaging; magnetic field; millisecond; next generation; novel; programs; prospective test; radio frequency; real-time images; reconstruction; respiratory imaging; simulation; soft tissue; spatiotemporal; synergism; temporal measurement; ultrasound; volunteer

PROJECT SUMMARY This project will develop volumetric real-time magnetic resonance imaging (RT-MRI) technology on a novel 0.55 Tesla platform to provide improved assessment of the heart and airway in motion. Rationale: Volumetric real- time imaging by computed tomography and ultrasound have had a profound impact on our ability to understand and evaluate disorders involving movement and of moving organs. These modalities each have limitations that include ionizing radiation, obstructed visualization angles, and limited contrast. MRI is currently capable of slice- by-slice RT-MRI and a leap to volumetric would enable improved assessment of a wide range of heart and airway disorders. Innovation: NIH has developed a 0.55 Tesla MRI instrument, that we argue will enable a breakthrough in RT-MRI performance. This is due to substantially reduced off-resonance effects, substantially reduced tissue heating, and a leap in scan efficiency due to increased flexibility in the MRI pulse sequence. We propose an innovative intramural-extramural partnership and interdisciplinary team to explore this potential. Approach: The objective of this project is to develop and translate low-latency volumetric RT-MRI methods that provide unprecedented spatio-temporal resolution and spatial coverage and will benefit several heart and airway applications. Specifically, we will: 1- develop and technically validate volumetric RT-MRI data acquisition at the 0.55T field strength, 2- develop and technically validate low-latency volumetric RT-MRI reconstruction, artifact mitigation, and segmentation, and 3- clinically evaluate volumetric RT-MRI in two unique patient cohorts at the NIH Clinical Center where it is likely to make an immediate impact on care—patients with tracheomalacia and relapsing polychondritis (N=20), and patients undergoing MRI-guided invasive cardiac catheterization (N=20). Broader Impact: The proposed volumetric RT-MRI technology is generalizable and could benefit many additional applications, such as cardiac function assessment in arrhythmia, and upper airway assessment in obstructive sleep apnea. The intramural and extramural labs each offer unique and complementary expertise to achieve this ambitious technical development. Creation of this new intramural-extramural collaboration will benefit both research programs and lead to new synergies that include basic research, clinical translation, and training of the next generation of scientists and engineers.

项目概要 该项目将开发基于新型 0.55 体积实时磁共振成像 (RT-MRI) 技术 Tesla 平台可提供对运动中的心脏和气道的改进评估。 计算机断层扫描和超声波的时间成像对我们理解的能力产生了深远的影响 并评估涉及运动和移动器官的疾病。这些方式各自都有局限性。 包括电离辐射、可视角度受阻以及 MRI 目前能够进行切片的能力。 逐层 RT-MRI 和体积测量的飞跃将能够改善对大范围心脏和气道的评估 创新：NIH 开发了一种 0.55 特斯拉 MRI 仪器，我们认为这将实现突破。 这是由于显着减少了非共振效应，显着减少了组织。 由于 MRI 脉冲序列灵活性的提高，扫描效率得到飞跃。 创新的校内校外合作伙伴关系和跨学科团队来探索这一潜力：方法。 该项目的目标是开发和转化低延迟体积 RT-MRI 方法，提供 前所未有的时空分辨率和空间覆盖范围，将有利于多个心脏和气道 具体来说，我们将： 1- 开发并在技术上验证体积 RT-MRI 数据采集。 0.55T 场强，2- 开发并技术验证低延迟体积 RT-MRI 重建、伪影 缓解和分割，以及 3- 在两个独特的患者队列中对体积 RT-MRI 进行临床评估 NIH 临床中心，该中心可能会对气管软化症患者的护理产生直接影响 复发性多软骨炎 (N=20) 和接受 MRI 引导的侵入性心导管插入术的患者 (N=20)。 更广泛的影响：所提出的体积 RT-MRI 技术是可推广的，可以使许多其他人受益 应用，例如心律失常的心脏功能评估和阻塞性上呼吸道评估 睡眠呼吸暂停实验室和校外实验室均提供独特且互补的专业知识来实现​​这一目标。 雄心勃勃的技术发展将使双方受益。 研究计划并带来新的协同效应，包括基础研究、临床转化和培训 下一代科学家和工程师。