New Hardware and Software Developments for Improving Prostate Metabolic MR Imaging

用于改善前列腺代谢 MR 成像的新硬件和软件开发

基本信息

批准号：
10680043
负责人：
Daniel Tewelde Gebrezgiabhier
金额：
$ 4.02万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10680043
关键词：
3-Dimensional 3D Print Address African American African-American Graduate Student Anatomy Anterior Award Beds Biomedical Engineering Biomedical Research Biopsy Black race Cancer Patient Clinical Clinical Management Clinical Research Code Collaborations Complex Coupling Detection Development Development Plans Disease Distant Education Electronics Elements Eligibility Determination Engineering Extracapsular Fellowship Frequencies Funding Geometry Goals Grant Head Health Image Incidence Infrastructure Joints Knowledge Learning Liver Localized Malignant Neoplasm Magnetic Resonance Imaging Malignant Neoplasms Malignant neoplasm of prostate Measurement Measures Metabolic Methods Modernization National Research Service Awards Neck Neoplasm Metastasis Newly Diagnosed Noise Not Hispanic or Latino Nursing Research Organ Patients Performance Periprostatic Phase I Clinical Trials Prostate Prostatic Pyruvate RF coil Research Research Design Research Project Grants Research Training Residual state Risk Scanning Science Signal Transduction Site Software Design Staging Statistical Study Students Techniques Testing Time Training Underrepresented Minority Underrepresented Populations advanced disease advanced prostate cancer bone cancer imaging career career development clinical care computer design design design and construction detector experience graduate student healthy volunteer improved industry partner interest lymph nodes member men minority scientist molecular imaging mortality novel performance tests pre-doctoral professor programs prototype radiologist reconstruction research study safety testing simulation skills software development technology development transmission process treatment response ultrasound volunteer

项目摘要

Project Summary/Abstract The proposed F31 NRSA Predoctoral Fellowship to Promote Diversity in Health-Related Research project aims to develop new MR detector hardware and acquisition & analysis methods to enable a major improvement in the clinical management of prostate cancer. This is of relevance to all prostate cancer patients, but also especially for under-represented minorities. African-American men have the world's highest incidence of prostate cancer and a more than two-fold higher mortality rate compared with whites. Also, African-American men have twice the risk of non-Hispanic whites for presenting with advanced-stage prostate cancer. This means that it is important to identify and stage aggressive, advanced prostate cancer accurately in this under-represented population. Prior studies by our group have been focused on improved MR molecular imaging of primary, organ- confined prostate-cancer and detecting response to therapy in bone and liver (distant) metastases. The PI, an African-American graduate student, has designed the proposed research training in this diversity fellowship project to focus on developing novel 13C/1H RF detector hardware and methods for increased HP [1-13C]pyruvate & 1H mpMRI sensitivity and coverage to detect aggressive cancers within the prostate and local spread to the prostatic bed & adjacent lymph-nodes. This is important for newly diagnosed patients and of particular relevance for African-American patients who more often present with advanced stage disease that has extra-capsular spread beyond the prostate and to nearby lymph nodes. As shown in his attached biosketch and through his outstanding initial research, the candidate is a highly motivated, successful trainee who meets the eligibility criteria as an African-American graduate student and will benefit greatly from this fellowship in terms of his research, education, and efforts to promote diversity in biomedical research. This project was designed by the PI applicant (with sponsor input & guidance) to fit his career goal of becoming a professor leading advanced MRI technology development to improve the clinical care of prostate cancer patients specifically, and patients with other deadly diseases in general. This award will also enable the PI candidate to promote diversity within the joint Bioengineering program at UC Berkeley and UCSF and ultimately science nationally to expand the number and input of under-represented minority scientists especially in the field of Bioengineering. He has been highly active in promoting diversity currently as a UC BioE graduate student and a member of Black Graduate Engineering and Science Students (BGESS). The diversity fellowship career development plan is designed to expand the scientific knowledge and independent research capabilities of the candidate. The goals are to: 1) Improve knowledge and research skills in MR hardware and acquisition methods; 2) Learn research study design and conduct; 3) Statistical and clinical study considerations; and 4) the conduct of first-rate research designed to ultimately improve prostate cancer imaging of newly diagnosed patients presenting with advanced disease.

项目概要/摘要拟议的 F31 NRSA 博士前奖学金旨在促进健康相关研究的多样性项目的目标开发新的 MR 探测器硬件以及采集和分析方法，以实现重大改进前列腺癌的临床管理。这与所有前列腺癌患者相关，但尤其重要对于代表性不足的少数群体。非裔美国男性前列腺癌发病率全球最高与白人相比，死亡率高出两倍多。此外，非洲裔美国男性有两次非西班牙裔白人患晚期前列腺癌的风险。这意味着它是在这个代表性不足的地区，准确识别侵袭性晚期前列腺癌并对其进行分期非常重要人口。我们小组之前的研究重点是改善原发性、器官的 MR 分子成像。局限性前列腺癌并检测骨和肝（远处）转移治疗的反应。 PI，一个非裔美国研究生，设计了这项多样性奖学金中拟议的研究培训项目重点开发新型 13C/1H RF 检测器硬件和方法以提高 HP [1-13C]丙酮酸盐 & 1H mpMRI 灵敏度和覆盖范围可检测前列腺内的侵袭性癌症和局部扩散到前列腺的癌症前列腺床和邻近淋巴结。这对于新诊断的患者很重要，并且特别相关对于经常出现有囊外病变的晚期疾病的非洲裔美国患者扩散到前列腺以外并到达附近的淋巴结。正如他所附的简历和他出色的初步研究所示，该候选人是一位高度积极进取、成功的实习生，符合非裔美国研究生的资格标准，并且愿意在他的研究、教育和促进多样性的努力方面，他从这项奖学金中受益匪浅。生物医学研究。该项目由 PI 申请人设计（在赞助商的意见和指导下）以适合他的要求职业目标是成为一名教授，领导先进的 MRI 技术开发，以改善临床护理特别是前列腺癌患者，以及一般患有其他致命疾病的患者。该奖项还将使 PI 候选人能够促进加州大学伯克利分校和加州大学旧金山分校联合生物工程项目的多样性最终在全国科学界扩大代表性不足的少数族裔科学家的数量和投入尤其是在生物工程领域。目前，作为加州大学生物工程师学院 (UC BioE) 的一员，他一直非常积极地促进多样性研究生和黑人研究生工程和科学学生 (BGESS) 的成员。多样性奖学金职业发展计划旨在扩展科学知识和独立研究候选人的能力。目标是： 1) 提高 MR 硬件和技术方面的知识和研究技能获取方法； 2）学习研究设计和实施； 3) 统计和临床研究考虑因素； 4) 进行一流的研究，旨在最终改善新发现的前列腺癌成像确诊患有晚期疾病的患者。