Multi-parametric anthropomorphic MRI Phantoms technology for reliable and reproducible structural and quantitative MRI

多参数拟人 MRI Phantoms 技术可实现可靠且可重复的结构和定量 MRI

• 批准号: 10729161
• 负责人: Ana Claudia Arias
• 金额: $ 61.04万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-08 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729161
• 关键词: 3-Dimensional; 3D Print; Acceleration; Address; Air; Anatomy; Biological; Brain; Chemicals; Clinic; Clinical; Collaborations; Color; Crosslinker; Data Science; Defect; Development; Diffusion; Educational workshop; Ensure; Equipment; Evaluation; Exhibits; Fatty acid glycerol esters; Fingerprint; Gel; Geometry; Head; Healthcare; Heterogeneity; Human; Hydrogels; Image; Imaging Phantoms; Industrialization; Internet; Liquid substance; Machine Learning; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Methods; Modeling; Paper; Permeability; Plastics; Predisposition; Printing; Process; Property; Protons; Publishing; Quality Control; Recommendation; Relaxation; Reproducibility; Resolution; Scanning; Shapes; Shoulder; Signal Transduction; Site; Slice; Source; Speed; Standardization; Structure; Techniques; Technology; Testing; Thinness; Time; Tissues; Variant; Viscosity; Water; Work; biomarker discovery; bone; clinical translation; deep learning; density; design; digital; digital twin; fabrication; human subject; improved; manufacture; manufacturing process; millimeter; monomer; novel strategies; personalized diagnostics; precision medicine; reconstruction; skills; sound; three dimensional structure; tool; validation studies

Abstract We aim to develop tools for ground-truth phantoms for quantitative and structural MRI (qMRI). qMRI aims to acquire maps of physical or chemical variables that can be measured in physical units and compared between tissue regions and among subjects. In contrast, most clinical MRI acquisitions are only qualitative, i.e. “weighted images”, and not quantitative. While qMRI has the potential to improve precision diagnostics and medicine, it has been traditionally hampered by significant barriers such as imaging speed, computational practicalities, and reproducibility and repeatability of MR measurements. The variability between scanners and human subjects and the lack of ground truth in biological tissues fundamentally challenge the development, testing and standardization of qMRI techniques. The National Institute of Standards and Technology (NIST) hosted workshops working towards standardizing qMRI. The resulting recommendation paper highlighted a list of outstanding needs. The proposed project aims to address these unmet needs by developing materials, technology, tools and processes for manufacturing quantitative anthropomorphic MRI phantoms. Current state- of-the-art solutions for manufacturing MRI phantoms often use discrete compartments or geometrical shapes filled with chemical solutions representing a single physical parameter. In contrast, our proposed novel approach will enable fabrication of phantoms that truly mimic the contrast heterogeneity of tissue in 3D. These will include proton density, T1, T2, T2* relaxation times, magnetic susceptibility, diffusion, fat fraction, air-tissue field- inhomogeneity, relative conductivity, electric permittivity and magnetic permeability. If successful, this will be the first time that such a comprehensive set of MRI parameters is accomplished in a tissue-mimicking phantom. Based on our preliminary work on quantitative anatomy mimicking slice phantoms, we propose two approaches: (a) Quantitative 3D stack of thin slices. This approach is inexpensive, easy to reproduce by labs with moderate equipment and skills. (b) An advanced approach of boundaryless fully 3D phantoms that will be fabricated via inkjet 3D printing of hydrogels and plastics and would enable true high resolution 3D structures with heterogeneity that mimics human anatomy. In collaboration with leading industrial partners, we will validate and disseminate our technology. Our proposal is motivated by a rising need for quantitative measurements in MRI driven by precision medicine and the use of data science tools for biomarker discovery. With the rise of methods such as fingerprinting, and accelerated reconstruction, quantitative MRI (qMRI) is closer to the clinics than ever. The proposed quantitative MRI phantom will mimic the complexity of tissue structure and contrast mechanism that are necessary to ensure the accuracy of qMRI. If successful, the project will greatly facilitate the development and clinical translation of qMRI, making MRI accurate, precise, and quantitative – thus enabling precision diagnostic and discoveries that will directly improve healthcare.

抽象的 我们的目标是开发用于定量和结构 MRI (qMRI) 的真实模型工具。 获取可以用物理单位测量并在之间进行比较的物理或化学变量图 相比之下，大多数临床 MRI 采集只是定性的，即。 虽然 qMRI 有潜力改善精确诊断和医学，但它 传统上一直受到成像速度、计算实用性等重大障碍的阻碍 MR 测量的再现性和可重复性。扫描仪和人类受试者之间的差异。 生物组织中缺乏基本事实从根本上挑战了开发、测试和 qMRI 技术的标准化由美国国家标准与技术研究院 (NIST) 主办。 致力于标准化 qMRI 的研讨会所产生的建议文件重点列出了以下内容。 拟议的项目旨在通过开发材料来解决这些未满足的需求， 用于制造定量拟人 MRI 模型的技术、工具和流程 当前状态。 用于制造 MRI 体模的最先进的解决方案通常使用离散的隔间或几何形状 相比之下，我们提出的新方法充满了代表单一物理参数的化学溶液。 将能够制造真正模仿 3D 组织对比度异质性的模型。 质子密度、T1、T2、T2* 弛豫时间、磁化率、扩散、脂肪分数、空气组织场- 如果成功，这将是不均匀性、相对电导率、介电常数和磁导率。 首次在模仿组织的模型中完成如此全面的 MRI 参数设置。 基于我们对模拟切片模型的定量解剖学的初步工作，我们提出了两种方法： (a) 定量 3D 薄片堆叠 这种方法成本低廉，易于由中等水平的实验室重现。 (b) 一种先进的无边界全 3D 模型制造方法。 水凝胶和塑料的喷墨 3D 打印，将实现真正的高分辨率 3D 结构 我们将与领先的工业合作伙伴合作，验证和模仿人体解剖学的异质性。 传播我们的技术是由于对 MRI 定量测量的需求不断增长。 随着精准医学和使用数据科学工具发现生物标志物的方法的兴起，推动了这一趋势。 例如指纹识别和加速重建，定量 MRI (qMRI) 比以往任何时候都更接近临床。 所提出的定量 MRI 模型将模拟组织结构和对比机制的复杂性 如果成功，该项目将极大地促进其发展。 qMRI 的临床转化，使 MRI 准确、精确和定量 – 从而实现精确性 将直接改善医疗保健的诊断和发现。