North Carolina A&T University-Wake Forest Cancer Center partnership (2 of 2)

北卡罗来纳州A

• 批准号: 7691356
• 负责人: STEVEN A AKMAN
• 金额: $ 10.32万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7691356
• 关键词: 3-hydroxybutanal; Agriculture; Animal Cancer Model; Animal Model; Biological Assay; Biology; Boronic Acids; Brain Neoplasms; CCL7 gene; Cancer Biology; Cancer Center; Cell Line; Cell Mobility; Cells; Chemistry; Chemoprevention; Chemopreventive Agent; Collaborations; Comprehensive Cancer Center; Comprehensive Cancer Center of Wake Forest University; Computational Biology; DU145; Data; Doctor of Philosophy; Educational process of instructing; Engineering; Enrollment; Enzymes; Evaluation; Faculty; Fostering; Funding; Funding Agency; GSTP1 gene; Genetic; Glioblastoma; Goals; Grant; Growth; Hour; In Vitro; Incidence; Institution; Joints; Knock-out; LNCaP; Laboratories; Malignant Epithelial Cell; Malignant Neoplasms; Malignant neoplasm of prostate; Master' s Degree; Measurement; Mentors; Methods; Minority; Modeling; Mus; NAD(P)H dehydrogenase (quinone) 1, human; NQO1 gene; North Carolina; PTEN gene; Phase; Physical condensation; Pilot Projects; Polyunsaturated Fatty Acids; Preparation; Process; Production; Prostate; Prostate carcinoma; Research; Research Project Grants; Resistance; Reverse Transcriptase Polymerase Chain Reaction; Role; Structure-Activity Relationship; Students; Testing; Therapeutic; Universities; Western Blotting; Writing; anticancer research; base; cancer cell; cancer genomics; cancer health disparity; cancer therapy; carcinogenesis; career development; cytotoxicity; enzyme activity; evidence base; forest; health disparity; in vivo; in vivo Model; innovation; interest; mouse model; novel; outreach; prevent; professor; programs; transcription factor; treatment strategy

DESCRIPTION (provided by applicant): This P20 proposal presents a research and educational partnership between the Wake Forest University Comprehensive Cancer Center (WFUCCC) and the Departments of Biology and Chemistry of North Carolina Agricultural and Technical University (NC A&T). The objectives of the partnership are: (1) to foster cancer research collaborations between WFUCCC and NC A&T, especially research focused on cancer disparities and to facilitate the career development of minority cancer research faculty at NC A&T through collaborations with and mentoring provided by the WFUCCC; (2) to foster interest in obtaining a PhD in cancer biology among minority undergraduate and Master's degree students at NC A&T. To achieve the first objective, the P20 will provide pilot funds for two collaborative research projects: (1) Drs. Suzy Torti and Yong Chen of the WFUCCC will mentor and collaborate with Dr. Marion Franks, Assistant Professor of Chemistry at NC A&T, on a project to synthesize and evaluate novel benzylidenes as prostate cancer chemopreventive agents; (2) Dr. Waldemar Debinski, Director of the Brain Tumor Center of the WFUCCC, will mentor and collaborate with Dr. Patrick Martin, Assistant Professor of Biology at NC A&T on a project to understand the role of transcription factor Fra1 in glioblastoma cell mobility and resistance to therapeutics. To achieve the second objective: (1) Selected RISE, MARC, and BLEND program undergraduates at NC A&T will participate in wet laboratory, computational biology, or health disparity outreach projects mentored by WFUCCC faculty; (2) Each pilot project team will select at least one NC A&T Master's degree student to ; participate in the project. The students will be offered the option of continued participation in the projects as PhD students in Cancer Biology at WFU; (3) WFUCCC and NC A&T faculty will collaborate to develop didactic teaching modules in cancer genomics and animal models of cancer for currently ongoing coursework at NC A&T. By the conclusion of the P20 it is expected that: (1) Drs. Franks and Martin and their WFUCCC collaborators will be writing joint RO1s; (2) The WFUCCC and NC A&T will be writing an R25 bridge application to support enrollment of NC A&T students in the PhD program in Cancer Biology at WFU.

描述（由申请人提供）：该P20提案提出了Wake Forest大学综合癌症中心（WFUCCC）与北卡罗来纳州农业技术大学（NC A＆T）生物学和化学部门之间的研究和教育伙伴关系。该合作伙伴关系的目标是：（1）促进WFUCCC和NC A＆T之间的癌症研究合作，尤其是针对癌症差异的研究，并通过与WFUCCC提供的合作和指导来促进NC A＆T少数民族癌症研究学院的职业发展； （2）为了促进NC A＆T的少数本科生和硕士学位学生中癌症生物学博士学位的兴趣。为了实现第一个目标，P20将为两个协作研究项目提供试点资金：（1）Drs。 WFUCCC的Suzy Torti和Yong Chen将与NC A＆T化学助理教授Marion Franks博士合作并合作，以合成和评估新颖的苯甲酰烯甲烷为前列腺癌化学预防剂； （2）WFUCCC脑肿瘤中心主任Waldemar Debinski博士将与NC A＆T生物学助理教授Patrick Martin博士进行指导和合作，以了解转录因子FRA1在胶质母细胞瘤细胞移动性中的作用和对治疗疗法的抗性。为了实现第二个目标：（1）NC A＆T的选定Rise，MARC和Blend计划本科生将参加由WFUCCC教师指导的湿实验室，计算生物学或健康差异外展项目； （2）每个飞行员项目团队将至少选择一个NC A＆T硕士学位学生；参加该项目。将为学生提供继续参与项目的选择，作为WFU癌症生物学的博士生； （3）WFUCCC和NC A＆T教师将合作开发癌症基因组学和动物模型中的教学模块，以目前在NC A＆T的正在进行的课程。根据P20的结论，可以预期：（1）Drs。弗兰克斯（Franks）和马丁（Martin）及其WFUCCC合作者将撰写联合RO1； （2）WFUCCC和NC A＆T将编写R25桥应用程序，以支持WFU癌症生物学博士学位计划的NC A＆T学生的入学。