MAPP Research Network Tissue Analysis and Technology Core

MAPP 研究网络组织分析和技术核心

• 批准号: 9120855
• 负责人: M. Scott Lucia
• 金额: $ 49.33万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-09 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120855
• 关键词: Adopted; Aliquot; Archives; Area; Biochemical; Biological; Biological Assay; Biological Markers; Bladder; Blood; Body Fluids; Chronic Fatigue Syndrome; Clinic; Clinical; Code; Collection; Colorado; Communication; Consent; Creatinine; DNA; Data; Data Coordinating Center; Diagnosis; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Etiology; Fibromyalgia; Fractionation; Genomics; Genotype; Goals; Health Insurance Portability and Accountability Act; Housing; Individual; Institutional Review Boards; Irritable Bowel Syndrome; Malignant Neoplasms; Measurement; Measures; Medical; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Pain; Pain Research; Pathway interactions; Patients; Pattern; Pelvic Pain; Pelvis; Phase; Phenotype; Platelet Factor 4; Practice Guidelines; Procedures; Process; Proteins; Proteomics; Quality Control; Research Personnel; Residual state; Resources; Role; Sampling; Sensory; Services; Site; Specimen; Specimen Handling; Statistical Models; Symptoms; Syndrome; Technology; Testing; Time; Tissues; United States National Institutes of Health; Universities; Urine; Work; biobank; biological research; chronic pelvic pain; clinical practice; cohort; instrument; interdisciplinary approach; medical specialties; meetings; neuroimaging; operation; pain symptom; potential biomarker; public health relevance; repository; response; sample collection; screening; success; symptomatic improvement; urinary; urologic

DESCRIPTION (provided by applicant): This is an application from the Tissue Analysis and Technology Core (TATC), currently housed at the University of Colorado Anschutz Medical Campus (UCAMC), to continue participation in the MAPP Research Network (RN) in response to RFA-DK-13-507 circulated on 8/23/2013. The primary responsibilities of the TATC will be to support the trans-MAPP longitudinal Symptom Patterns Study (SPS) by providing expertise and services in the areas of 1) biospecimens collection, processing, management and distribution for trans-MAPP proteomic, infectious etiology, and genomic studies, 2) centralized ELISA and analyte testing including protein and creatinine quantifications and quality control testing on MAPP biospecimens, and 3) centralized genotyping of the trans-MAPP cohort. The TATC will serve as the repository for all body fluid specimens collected during the MAPP SPS; process these specimens using customized, quality controlled, and documented best practice procedures; and to provide these biospecimens to MAPP investigators to meet the objectives of the MAPP RN. The TATC will collaborate closely with the MAPP Data Coordinating Center (DCC) and Executive Committee to ensure that the goals of the MAPP RN are successfully met. The TATC will meet all NIH quality standards and will provide specimens to researchers according to IRB, HIPAA and NIDDK procedures that protect the confidentiality of all consented patients whose tissue and blood are archived. In accordance with the terms set forth in the RFP, the TATC will prepare all residual samples from the MAPP RN for transfer to the NIDDK Central Biorepository. The TATC will work with the NIDDK Central Biorepository to coordinate procedures for collection, coding, storage and eventual transfer as directed by the NIDDK.

描述（由申请人提供）：这是来自目前位于科罗拉多大学安舒茨医学校区 (UCAMC) 的组织分析和技术核心 (TATC) 的申请，旨在继续参与 MAPP 研究网络 (RN)，以响应RFA-DK-13-507 于 2013 年 8 月 23 日分发。 TATC 的主要职责是通过提供以下领域的专业知识和服务来支持跨 MAPP 纵向症状模式研究 (SPS)：1) 跨 MAPP 蛋白质组学、感染性病因学和生物样本收集、处理、管理和分发。基因组研究，2) 集中 ELISA 和分析物测试，包括 MAPP 生物样本的蛋白质和肌酐定量和质量控制测试，以及 3) 集中基因分型反式 MAPP 队列。 TATC 将作为 MAPP SPS 期间收集的所有体液样本的储存库；使用定制的、质量控制的和记录的最佳实践程序处理这些样本；并向 M​​APP 研究人员提供这些生物样本，以实现 MAPP RN 的目标。 TATC 将与 MAPP 数据协调中心 (DCC) 和执行委员会密切合作，确保成功实现 MAPP RN 的目标。 TATC 将满足所有 NIH 质量标准，并将根据 IRB、HIPAA 和 NIDDK 程序向研究人员提供样本，以保护所有组织和血液存档的同意患者的机密性。根据 RFP 中规定的条款，TATC 将准备 MAPP RN 的所有残留样本，以便转移到 NIDDK 中央生物样本库。 TATC 将与 NIDDK 中央生物储存库合作，按照 NIDDK 的指示协调收集、编码、存储和最终转移的程序。