CRCNS: Decision-making in flying insects using multisensory cues

CRCNS：使用多感官线索进行飞行昆虫决策

基本信息

批准号：
9110955
负责人：
Michael H Dickinson
金额：
$ 24.16万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9110955
关键词：
Address Affect Air Algorithm Design Algorithms Appetitive Behavior Area Behavior Behavioral Behavioral Model Body Surface Brain Breathing Carbon Dioxide Chemicals Communication Communities Complex Computing Methodologies Conflict (Psychology)Cues Culicidae Data Decision Making Electrophysiology (science)Elements Engineering Environment Environmental Wind Exhibits Female Flying body movement Goals Head Heating Human Individual Insecta K-12 Education Laboratories Lead Left Location Methods Modality Modeling Motor Movement Nervous system structure Neurons Normal Statistical Distribution Odors Physiology Postdoctoral Fellow Preparation Process Property Psychophysics Recording of previous events Research Resources Sensory Sensory Process Shapes Signal Transduction Site Source Stimulus Structure Temperature Time Training Variant Vision Visual Weight Work approach behavior base behavioral outcome behavioral response computational neuroscience design disease transmission education research experience feeding graduate student human disease information model millisecond multisensory neuromechanism novel outreach relating to nervous system research study response sensor sensory input sensory system simulation social media statistics teacher theories undergraduate student vector

项目摘要

DESCRIPTION (provided by applicant): This project addresses the fundamental question: how does the history of sensory experience affect behavioral decision-making? We address this problem in the neuroethological context of mosquito host seeking, in which the presence of thermal and carbon dioxide signals trigger and direct search behavior. This project has several novel aspects. It will quantitatively explore this synergistic stimulus interaction in the context f a natural behavior and develop models for multisensory integration based both on behavioral and neural data. It will address the spatial variations in the statistical structure of olfactory and thermal stimuli through recordings and direct numerical simulations, and examine whether the universal properties of turbulently advected scalar fields can provide sensory evidence for source location and shape neural responses. We will obtain novel neural recordings in response to multiple time-varying inputs. By a developing tethered flight preparation for mosquitoes, we will be able to record neural activity during constrained flight and directly relate sensory neural responses to behavioral outcomes. The results from this project may help in the design of noninvasive mosquito repellents or attractants and so have an impact on disease transmission. The work may also have impact beyond insect physiology in the design of algorithms for novel sensors in the olfactory domain. Additional broader impacts from this project arise from educational and community engagement through interdisciplinary training of undergraduate and graduate students and postdoctoral fellows; active involvement of our research groups in the broader goals of integrated education and research experiences in the areas of Computational Neuroscience and Neural Engineering through new campus-wide initiatives; communication of our results to the community through a wide variety of social media; and participation in outreach activities to teachers and K-12 classrooms.

描述（由申请人提供）：该项目解决了一个基本问题：感官体验的历史如何影响行为决策？我们在蚊子宿主寻找的神经行为学背景下解决这个问题，其中热和二氧化碳信号的存在触发和直接搜索行为。该项目有几个新颖的方面。它将在自然行为的背景下定量探索这种协同刺激相互作用，并开发基于行为和神经数据的多感官整合模型。它将通过记录和直接数值模拟来解决嗅觉和热刺激统计结构的空间变化，并检查湍流平流标量场的普遍特性是否可以为源位置和塑造神经反应提供感官证据。我们将获得响应多个时变输入的新颖的神经记录。通过开发蚊子的系留飞行准备，我们将能够记录受限飞行期间的神经活动，并直接关联感觉神经对行为结果的反应。该项目的结果可能有助于设计非侵入性驱蚊剂或引诱剂，从而对疾病传播产生影响。这项工作还可能对昆虫生理学之外的嗅觉领域新型传感器的算法设计产生影响。该项目的其他更广泛的影响来自于通过本科生、研究生和博士后研究员的跨学科培训进行教育和社区参与；通过新的校园范围内的举措，我们的研究小组积极参与计算神经科学和神经工程领域的综合教育和研究经验的更广泛目标；通过各种社交媒体向社区传达我们的成果；参与针对教师和 K-12 教室的外展活动。