Systems Genetics of Alcoholism: Network-based Approaches for Genetics Association

酗酒的系统遗传学：基于网络的遗传学关联方法

基本信息

批准号：
9360720
负责人：
ROHAN Hugh Craig PALMER
金额：
$ 16.08万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-20 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9360720
关键词：
Accounting Adult Affect Age Alcohol abuse Alcohol dependence Alcoholism Alcohols Algorithms American Aminobutyric Acids Architecture Attenuated Bayesian Modeling Bioinformatics Biological Biology Biometry Chromosome 1 Chromosome 5 Collaborations Complex Copy Number Polymorphism Data Databases Diagnosis Diagnostic Disease Drug Addiction EP300 gene Educational workshop Emerging Technologies Environment Environmental Risk Factor Ethnic Origin Event-Related Potentials Future Gender Gene Cluster Gene Proteins Genes Genetic Genetic Polymorphism Genetic Research Genetic Variation Genetic study Genomics Genotype Goals Grant Graph Heterogeneity Individual Institutes Joints K-Series Research Career Programs Knowledge Lead Learning Link Major Depressive Disorder Manuscripts Mental disorders Mentors Mentorship Methods Modeling Molecular Nature Network-based Neural Pathways Pathway interactions Pharmacologic Substance Phenotype Predisposition Prevention Problem Solving Public Health Receptor Gene Recruitment Activity Research Research Methodology Research Training Resources Role Sampling Sampling Studies Scientist Single Nucleotide Polymorphism Map Statistical Methods Structure Sum Surveys System Systems Biology Techniques Testing Training Variant alcohol and other drug alcohol use disorder alpha synuclein anti social attenuation base biological systems career cost effective data mining database of Genotypes and Phenotypes drinking endophenotype gene interaction genetic association genetic variant genetics of alcoholism genome sequencing genome wide association study improved innovation meetings network models neurophysiology new technology novel novel strategies personalized approach phenotypic data programs public health relevance relating to nervous system sequencing platform study population success theories tool whole genome

项目摘要

DESCRIPTION (provided by applicant): This Mentored Research Scientist Career Development Award will afford Dr. Rohan Palmer focused training for his programmatic line of research in the genetics of alcohol dependence and related phenotypes (AD). Given that gene identification studies (in particular genomewide association studies) on alcoholism are challenged by the fact that alcoholism is a multifactorial disorder influenced by multiple interacting genes, each with small effect, the

描述（由申请人提供）：该导师研究科学家职业发展奖将为 Rohan Palmer 博士提供针对酒精依赖和相关表型 (AD) 遗传学研究的重点培训。鉴于酒精中毒的基因鉴定研究（特别是全基因组关联研究）受到以下事实的挑战：酒精中毒是一种受多个相互作用基因影响的多因素疾病，每个基因的影响都很小，因此

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

HPA axis multilocus genetic profile score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers.

HPA 轴多位点遗传谱评分可调节人际压力对抑郁母亲后代抑郁症状预期增加的影响。

DOI：
发表时间：
2017-11
期刊：
影响因子：
4.6
作者：
Feurer, Cope;McGeary, John E;Knopik, Valerie S;Brick, Leslie A;Palmer, Rohan H;Gibb, Brandon E
通讯作者：
Gibb, Brandon E

Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype.

母亲抑郁对儿童沉思的影响：CRHR1 TAT 单倍型的调节。

DOI：
发表时间：
2016
期刊：
影响因子：
2.6
作者：
Woody, Mary L;Kudinova, Anastacia Y;McGeary, John E;Knopik, Valerie S;Palmer, Rohan H C;Gibb, Brandon E
通讯作者：
Gibb, Brandon E

Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings.

抑郁母亲的孩子注意力偏差的眼动追踪指数：多基因影响有助于澄清以前的混合发现。

DOI：
发表时间：
2016-05
期刊：
影响因子：
3.3
作者：
Owens, Ma;Harrison, Ashley J;Burkhouse, Katie L;McGeary, John E;Knopik, Valerie S;Palmer, Rohan H C;Gibb, Brandon E
通讯作者：
Gibb, Brandon E

Neural reward responsiveness in children who engage in nonsuicidal self-injury: an ERP study.

参与非自杀性自残的儿童的神经奖励反应：一项 ERP 研究。