Stroke Trials Network - Regional Coordinating Stroke Centers

中风试验网络 - 区域中风协调中心

• 批准号: 9122507
• 负责人: Shyam Prabhakaran
• 金额: $ 37.08万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9122507
• 关键词: Academic Medical Centers; Acute; Adult; Aging; Agreement; Alteplase; Area; Blood Vessels; Brain hemorrhage; Caring; Cause of Death; Cessation of life; Chicago; Child; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Conduct Clinical Trials; County; Data; Development; Disease; Elderly; Emergency Medicine; Emergency treatment; Enrollment; Ensure; Environment; Faculty; Fellowship; Fostering; Funding; Future; Growth and Development function; Health; Hospitals; Individual; Industry; Institutes; Institutional Review Boards; International; Ischemic Stroke; Leadership; Medical Research; Mentors; Mentorship; Neurological emergencies; Neurology; Neurorehabilitation; Neurosciences; Outcome; Outcomes Research; Patient Recruitments; Patients; Pediatric Hospitals; Pediatric Neurology; Phase; Phase III Clinical Trials; Population; Prevention trial; Procedures; Process; Qualifying; Recording of previous events; Recruitment Activity; Registries; Rehabilitation therapy; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Role; Sample Size; Seminal; Site; Societies; Stroke; System; Testing; Training Programs; Translational Research; Translations; United States; United States National Institutes of Health; Universities; Work; acute stroke; arm; base; career; clinical biomarkers; cooking; cost; data management; disability; effective therapy; implementation trial; improved outcome; medical schools; metropolitan; nervous system disorder; neurosurgery; patient population; response; statistics; stroke rehabilitation; stroke treatment; treatment trial; validation studies

DESCRIPTION (provided by applicant): There is a great need for effective treatments in stroke as the disease is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. As several recent trials illustrate, a key factor in developing breakthrough stroke treatments is the rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (RFA-NS-13-011). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) is a collaborative network of 7 centers in the Chicago metropolitan area: Northwestern Memorial Hospital (NMH), Lurie Children's Hospital (LCH), Rehabilitation Institute of Chicago (RIC) [all part of NU's McGaw Medical Center], the University of Chicago (UC), Rush University Medical Center (RUMC), Loyola University Chicago (LUMC), and the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County (CCH). We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals and their resources and investigators, the CSTC is uniquely qualified to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for network trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.

描述（由申请人提供）：由于中风是美国死亡和残疾的主要原因，因此非常需要有效的中风治疗方法。尽管科学和技术取得了进步，但对中风患者的临床结果益处的转化仍然有限。正如最近的几项试验所表明的那样，开发突破性中风治疗方法的一个关键因素是快速执行临床试验，并提供足够的样本量、稳健的入组、及时完成以及跨站点的严格和统一的基础设施。 此申请是为了响应 NINDS 最近对 NINDS 卒中试验网络 (RFA-NS-13-011) 中的区域卒中协调中心 (RCC) 的请求。由西北大学 (NU) 的 RCC 领导的芝加哥中风试验联盟 (CSTC) 是一个由芝加哥都市区 7 个中心组成的协作网络：西北纪念医院 (NMH)、卢里儿童医院 (LCH)、芝加哥康复研究所 ( RIC）[NU 麦高医学中心的所有部分]、芝加哥大学 (UC)、拉什大学医学中心 (RUMC)、芝加哥洛约拉大学 (LUMC) 和Hektoen 医学研究所/库克县小约翰·H·斯特罗格医院 (CCH)。我们已经获得了机构支持，包括使用联合机构审查委员会流程（中央 IRB）的协议和主试验协议，以确保我们每个参与中心快速实施未来的试验。 RCC 旨在将资源、具有中风专业知识的多元化教职人员结合起来，并接触到从儿童到老年人、从急性治疗到康复的多种族中风患者群体。 CSTC 将参与急性中风、康复和预防试验，并拥有血管神经病学、神经外科、神经重症监护、神经放射学、介入神经放射学、神经康复、儿科神经病学和急诊医学领域研究人员的专业知识。聚集的研究人员拥有中风研究各个方面的背景，并在许多最近完成和正在进行的 NIH 和行业赞助的试验中发挥领导作用。该联盟拥有涵盖近 1000 万人的综合地理转诊基础，并在临床和科学领域拥有合作历史。凭借我们医院广阔的地理覆盖范围及其资源和研究人员，CSTC 具有独特的资格来提供多样化的中风患者群体，为网络试验提供综合的多学科和多机构专业知识和领导力，并确保对学员和研究人员的指导。寻求中风学术职业的初级教师。