Lower Gastrointestinal Cancer Studies

下消化道癌症研究

基本信息

批准号：
10702941
负责人：
Rashmi Sinha
金额：
$ 63.02万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10702941
关键词：
Achievement Adenomatous Polyps Age Assessment tool Biochemical Markers Blood Blood specimen Calories Collection Colonoscopy Colorectal Colorectal Adenoma Colorectal Neoplasms Control Groups DNA Data Detection Diet Diet Modification Dietary Assessment Dietary Factors Eating Elements Energy Intake Etiology Fatty acid glycerol esters Fiber Fibrinogen Folic Acid Follow-Up Studies Food Frequencies Future Genetic Polymorphism Genetic Predisposition to Disease Genomics Goals Health High grade dysplasia Hormones Hospitals Hour Incidence Intervention Investigation Lesion Leukocytes Malignant neoplasm of gastrointestinal tract Manuscripts Meat Medical center Methylation Military Personnel Minority Mutagens Non-Steroidal Anti-Inflammatory Agents Observational epidemiology Participant Polyp Prevention Trial Preparation Publishing Quality of life Questionnaires Randomized Randomized, Controlled Trials Records Recurrence Reporting Research Personnel Risk Risk Factors Sample Size Screening procedure Sigmoidoscopes Sigmoidoscopy Site Tissue Banks Tissue Sample Tobacco Tubular Adenoma United States Villous Woman base clinical center clinical investigation cohort colorectal cancer screening dietary effectiveness evaluation epidemiology study fruits and vegetables intervention program neoplastic recruit screening treatment arm

项目摘要

PPT:The PPT was a randomized, controlled trial being carried out at eight Clinical Centers in the United States. The dietary goals for the intervention arm were 20% of calories from fat, 18g fiber/1000 kcal, and 5-8 servings of fruits and vegetables (the exact number based on caloric intake). Three different dietary assessment instruments were used in the PPT: a modified Block/NCI Food Frequency Questionnaire (FFQ), Four Day Food Records (4DFR), and 24 Hour Recalls. Participants underwent colonoscopy again at baseline and at one (T1) and four (T4) years into the study. Blood specimens were collected on all participants annually. Recruitment went on from 1991-4. A total of 38,277 potential participants were screened at the eight Clinical Centers. Of these, 2079 were randomized into the study, with 1037 in the intervention and 1042 in the control group. The mean age of PPT participants at baseline was 61.5 years. 35% of participants are women, 10% minority. T4 colonoscopic endpoint assessment and active intervention were completed in early April, 1998. A report of the main study findings was published in 2000. years ago (New Engl J Med 2000; 342:1149-55). Additional manuscripts have been published, submitted, or are in preparation. The Continued Follow-up Study should has now been completed; a report is now in press.CONCeRN:Asymptomatic women were referred for colorectal screening to one of three regional military medical centers, including Bethesda Naval Hospital, from 1999 to 2002. Blood and tissue samples were collected as well as general health information, along with a detailed risk factor questionnaire. Dietary and biospecimen analyses are currently underway using data from the etiologic component of the study. These include an investigation of meat and meat-mutagens and the risk of colorectal adenoma as well as a study of genomic methylation of leukocyte DNA and colorectal adenoma risk, and modification by dietary folate.

PPT：PPT是一项随机对照试验，在美国的八个临床中心进行。干预臂的饮食目标是脂肪，18G纤维/1000 kcal和5-8份水果和蔬菜的卡路里的20％（基于热量摄入的确切数字）。 PPT中使用了三种不同的饮食评估工具：改良的块/NCI食品频率问卷（FFQ），四天的食物记录（4DFR）和24小时召回。参与者在基线时再次进行结肠镜检查，并在研究开始时（T1）和四个（T4）。每年收集所有参与者的血液标本。招聘从1991 - 4年进行。在八个临床中心筛选了总共38,277名潜在参与者。其中，2079年被随机分为研究，干预措施为1037，对照组为1042。基线PPT参与者的平均年龄为61.5岁。 35％的参与者是妇女，少数族裔10％。 T4结肠镜终点评估和主动干预于1998年4月上旬完成。主要研究结果的报告于2000年发表。几年前（New Engl J Med 2000; 342：1149-55）。其他手稿已出版，提交或正在准备。现在的后续研究应该已经完成；现在在印刷中。目前，使用研究的病因组成部分的数据正在进行饮食和生物测量分析。其中包括对肉类和肉类杂质的研究以及结直肠腺瘤的风险，以及对白细胞DNA和结直肠腺瘤风险的基因组甲基化的研究，以及饮食中叶酸的修饰。