Chicago Stroke Trials Consortium

芝加哥中风试验联盟

• 批准号: 10217267
• 负责人: Shyam Prabhakaran
• 金额: $ 31.08万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217267
• 关键词: Academic Medical Centers; Acute; Adult; Agreement; Area; Award; Blood Vessels; Brain hemorrhage; Caring; Cause of Death; Chicago; Child; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Community Hospitals; County; Development; Disease; Education; Elderly; Emergency Care; Emergency Medicine; Enrollment; Ensure; Environment; Ethnic group; Faculty; Fostering; Funding; Future; Geography; Growth and Development function; Hospitals; Illinois; Individual; Industry; Infrastructure; Institutes; Institutional Review Boards; International; Intervention; Lead; Leadership; Medical Research; Medical center; Mentors; Mentorship; National Institute of Neurological Disorders and Stroke; Network Infrastructure; Neurology; Neurosciences; Outcome; Patient Recruitments; Patients; Pediatric Hospitals; Pediatric Neurology; Peer Review; Prevention; Prevention approach; Prevention trial; Principal Investigator; Procedures; Process; Recording of previous events; Recovery; Rehabilitation therapy; Research; Research Personnel; Resources; Role; Sample Size; Site; Societies; Standardization; Stroke; Stroke prevention; System; Time; Training; Training Programs; Translational Research; Translations; United States; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Wisconsin; Work; acute stroke; aging population; base; career; clinical biomarkers; cohesion; cooking; cost; data management; disability; effective therapy; experience; improved; innovation; medical schools; metropolitan; multi-ethnic; multidisciplinary; neuroimaging; neurological rehabilitation; neuroprotection; neurosurgery; novel strategies; patient population; phase III trial; programs; recruit; response; statistics; stroke patient; stroke rehabilitation; stroke therapy; stroke trials; telerehabilitation; validation studies; working group

Stroke is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. Since 2013, a cohesive and integrated Stroke Trials Network has been working to develop breakthrough stroke treatments with an emphasis on rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (PAR-17-276). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) has been an integral part of the NIH StrokeNet. In this renewal application, we expand our network to include 12 centers in the Chicago and Milwaukee metropolitan areas: Northwestern Memorial Hospital, Lurie Children's Hospital, Shirley Ryan Ability Lab, (all part of NU's McGaw Medical Center), the University of Chicago, Rush University Medical Center, Loyola University Chicago, University of Illinois at Chicago, Medical College of Wisconsin, the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County, Central Dupage Hospital, Northwest Community Hospital, and Edward Hines, Jr. VA Hospital. We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals, their resources and investigators, and substantial contributions to StrokeNet during the initial award period, the CSTC is uniquely qualified to continue to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for StrokeNet trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.

中风是美国死亡和残疾的主要原因。尽管科学技术 尽管取得了进展，但对中风患者的临床结果益处的转化有限。自 2013 年以来， 具有凝聚力和综合性的中风试验网络一直致力于开发突破性的中风治疗方法 重点是快速执行具有足够样本量、稳健的入组、及时的临床试验 完成，以及跨站点严格和统一的基础设施。 此申请是为了响应最近 NINDS 对区域卒中协调中心的请求 (RCC) 在 NINDS 中风试验网络 (PAR-17-276) 中。芝加哥中风试验联盟 (CSTC) 领导 西北大学 (NU) 的 RCC 已成为 NIH StrokeNet 的组成部分。在这次更新中 应用程序后，我们将网络扩展到包括芝加哥和密尔沃基大都市区的 12 个中心： 西北纪念医院、Lurie 儿童医院、Shirley Ryan 能力实验室（均为 NU McGaw 的一部分） 医学中心）、芝加哥大学、拉什大学医学中心、芝加哥洛约拉大学、 伊利诺伊大学芝加哥分校、威斯康星医学院、赫克托恩医学研究所 研究/John H. Stroger, Jr. 库克县医院、中央杜佩奇医院、西北社区 医院和小爱德华·海因斯退伍军人管理局医院。我们已经争取了机构支持，包括达成协议 利用联合机构审查委员会流程（中央 IRB）和主试验协议来确保快速 从我们每个参与地点实施未来的试验。 RCC旨在整合资源， 拥有中风专业知识的多元化教师，并能接触到来自不同种族的中风患者 从儿童到老人，从急性治疗到康复。 CSTC 将参与急性中风、 康复和预防试验，并拥有血管神经病学、神经外科、 神经重症监护、神经放射学、介入神经放射学、神经康复、小儿神经病学和 急救医学。聚集的研究人员拥有中风研究各个方面的背景， 在许多最近完成和正在进行的 NIH 和行业赞助的试验中发挥领导作用。财团 拥有涵盖近 1000 万人的综合地理推荐基础，并且拥有 临床和科学工作中的合作。凭借我们医院广阔的地理覆盖范围， 他们的资源和研究人员，以及在初始奖励期间对 StrokeNet 的重大贡献， CSTC 具有独特的资格，可以继续为多样化的中风患者群体提供服务，提供综合的 StrokeNet 试验的多学科和多机构专业知识和领导力，并确保对 寻求中风学术职业的学员和初级教师。