2016 Membrane Transport Proteins: Translating Molecules to Medicine Gordon Research Conference and Seminar

2016膜转运蛋白：将分子转化为药物戈登研究会议及研讨会

基本信息

批准号：
9193325
负责人：
RAJINI RAO
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-11 至 2017-06-10
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9193325
关键词：
3-Dimensional Academia Accounting Address Anniversary Autistic Disorder Basic Science Big Data Biochemical Biogenesis Biological Carrier Proteins Cells Cessation of life Chemicals Climate Collaborations Communities Data Defect Development Diabetes Mellitus Discipline Disease Diuretics Drug Design Drug Targeting Employee Strikes Ensure Environment Europe Face Fluoxetine Fostering Funding Future Gender Genes Genetic Glucose Transporter Goals Government Health Hereditary Disease Hour Human Human Genome Industry Institution International Ion Channel Ion Pumps Ions Italy Lead Leadership Life Link Location Malignant Neoplasms Mediation Medicine Membrane Transport Proteins Mental Depression Mentors Metabolic Diseases Mind Mining Minority Mission Molecular Molecular Chaperones Mucolipidoses National Institute of Neurological Disorders and Stroke Neurotransmitters Nutrient Omeprazole Organism Organoids Orphan Participant Patients Persons Pharmaceutical Preparations Pharmacology Physiology Policies Postdoctoral Fellow Productivity Proton Pump Publishing Rare Diseases Recruitment Activity Regulation Reporting Research Research Personnel Resolution SK-Furosemide SLC12A3 gene Schizophrenia Science Scientist Selective Serotonin Reuptake Inhibitor Senior Scientist Site Stem cells Structure Students Syndrome System Techniques Technology Therapeutic Time Translating Translational Research Transmembrane Transport Ulcer Underrepresented Groups Underrepresented Minority Variant Vermont Woman Work base career clinically relevant cost design disability disease phenotype drug development graduate student human disease induced pluripotent stem cell inhibitor/antagonist innovation insight lectures member nervous system disorder notch protein parity peer peer coaching posters professional atmosphere professor serotonin transporter single molecule skills solute stem cell technology success symposium therapeutic target trafficking virtual

项目摘要

The 2016 Gordon Research Conference on Membrane Transporters titled “Translating Molecules to Medicine” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and contribute to a gamut of highly prevalent (autism, diabetes) as well as orphan and rare diseases (Mucolipidosis type 4, Christianson syndrome), membrane transporters remain largely untapped in their potential as therapeutic targets. The nine scientific sessions are highly interdisciplinary, bringing together topics and techniques that are not conventionally related: these include stem cell technology, 3D organoids, virtual mining of the chemical universe for inhibitors, and single molecule dynamics, as examples. Ample discussion time after each talk, daily poster sessions and afternoon free time allow plenty of opportunity for informal discussion, networking and forming new collaborations. A special Pharma session will help build consortia between industry and academics to tackle challenges in the drug development pipeline. The Keynote session will feature the GRC Alexander M. Cruickshank Lecture awardee, Dr. Nieng Yan, whose recent landmark high-resolution structures of human glucose transporters have captured the challenges and opportunities of this membrane transporter field. Approximately 150 participants will be drawn from industry, academia, research institutions and government and will span all career levels, ranging from early career investigators (graduate students, postdoctoral fellows) projected to comprise 50% of attendees, to mid-career and senior scientists and professors. This mix offers an ideal opportunity for vertical and peer mentoring, and networking, essential for the future health and productivity of this field. For the first time, we will host a pre-conference Graduate Research Seminar organized by, and exclusively for, young investigators. The GRS will include poster sessions, short talks and a Careers Panel with invited leaders from pharma, academia and publishing sectors, with a goal of fostering scientific and professional development and instilling confidence and leadership skills in student trainees and fellows. The organizers are committed to promote diversity and inclusion of women, minorities and persons of disability. To this end, our goal is to achieve gender parity (50%) in speakers and discussion leaders, and to increase the visibility of all underrepresented groups. Another innovative feature of this conference, the Power Hour, is a forum designed to address challenges that women face in science. To foster international reach, participants have elected to alternate the location of the conference between the US and Europe. Most recently, the conference was held in Vermont, and in 2016 the venue is Italy. The GRC provides seed money and negotiates costs directly with the conference site, to keep expenses at a minimum. This application seeks partial funding to cover registration costs for invited speakers, including women and minorities, and young investigators.

2016 年戈登膜转运蛋白研究会议，题为“将分子转化为医学” 将为临床相关且高度成药的研究带来迫切需要的转化焦点尽管它们占人类基因组的 10%，并且对多种疾病有贡献。高度流行（自闭症、糖尿病）以及孤儿病和罕见病（粘脂沉积症 4 型、Christianson 综合征），膜转运蛋白作为治疗靶点的潜力在很大程度上尚未开发。科学会议是高度跨学科的，汇集了非学科领域的主题和技术。传统相关：包括干细胞技术、3D 类器官、化学品虚拟采矿例如，抑制剂的宇宙和单分子动力学，每次演讲后都有充足的讨论时间，每日海报会议和下午的空闲时间为非正式讨论、交流提供了充足的机会建立新的合作关系将有助于在行业和制药业之间建立联盟。学者们共同应对药物开发过程中的挑战。主题演讲将以 GRC 为主题。 Alexander M. Cruickshank 讲座获奖者 Nieng Yan 博士，其近期具有里程碑意义的高分辨率结构人类葡萄糖转运蛋白抓住了这种膜转运蛋白的挑战和机遇大约150名参与者来自工业界、学术界、研究机构和政府，并将涵盖所有职业级别，从早期职业调查员（研究生，博士后研究员）预计将占与会者的 50％，其中包括职业生涯中期和高级科学家以及这种组合为垂直和同行指导以及网络提供了理想的机会，这对于该领域的未来健康和生产力，我们将首次举办毕业生会前活动。 GRS 专门为年轻研究人员组织的研究研讨会将包括海报。邀请来自制药、学术界和出版界的领导人参加会议、简短的谈话和职业小组，其目标是促进科学和专业发展并灌输信心和领导技能组织者致力于促进女性的多样性和包容性。为此，我们的目标是实现演讲者和残疾人的性别平等（50%）。讨论领导者，并提高所有代表性不足群体的知名度。这次会议“Power Hour”是一个旨在解决女性在科学领域面临的挑战的论坛。为了促进国际影响力，与会者选择在美国之间轮流举行会议最近，该会议在佛蒙特州举行，2016 年的举办地是意大利。提供种子资金并直接与会议地点协商费用，以将费用保持在最低限度。该申请寻求部分资金来支付受邀演讲者（包括女性和女性）的注册费用。少数民族和年轻的研究人员。