Training Program In Cellular and Molecular Medicine

细胞和分子医学培训计划

• 批准号: 10650362
• 负责人: RAJINI RAO
• 金额: $ 79.58万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650362
• 关键词: Molecular Medicine; Training Programs

PROJECT SUMMARY/ABSTRACT The mission of the training program in Cellular and Molecular Medicine (CMM) is to prepare Ph.D. scientists for laboratory research at the cellular and molecular level on topics with a direct impact on the understanding, diagnosis, treatment and prevention of human diseases. Through a series of tailored courses, small group discussions, individualized clinical exposure and laboratory research, Ph.D. candidates of this program will receive a rigorous training in scientific research and a thorough knowledge of human biology and human diseases. Consistent with the emphasis on translational research, most CMM faculty work in clinical settings, distributed over 22 clinical and basic science departments and 4 institutes within the Johns Hopkins School of Medicine and School of Public Health. Trainers will receive mentor training and are rigorously evaluated according to criteria of merit, mentorship ability and program fit. The current program size of 121 faculty and 115 students maintains ~ 1:1 faculty-student ratio by an active process of mentor recruitment, renewal and turnover to ensure the best training environment for Ph.D. candidates. A holistic review admits 20-24 trainees from a robust pool size of ~150 training grant eligible candidates, which recently increased by 40% with a doubling of underrepresented minority applications following an evidence-based decision to remove the GRE requirement. The training program will leverage institutional funds to defray tuition charges in all years, support administration and all program activities and guarantee trainee support. The first year curriculum will begin with the intensive Introduction to Human Body course that combines hands-on dissection of the human cadaver, virtual histology labs, in-class and e-lectures, and group presentations by students. Following a basic science curriculum covering principles in molecular biology, genetics, biochemistry and cell biology, accompanied by three 10-week laboratory rotations, the year will end with Introduction to Clinical Research and Cellular and Molecular Basis of Disease that covers a spectrum of clinically and/or socially relevant disorders of the human body, completing the cycle of the year from "book to bench to bedside". Other program-specific activities will include a Grant Writing workshop, a newly developed Rigor and Reproducibility in Research (3R) course and an individualized Bench to Bedside and Back (3B) clinical experience under the direction of a clinical co- mentor in years 3-4. The program sponsors an Annual Retreat, journal club and student-run research in progress seminar series. Structured career training opportunities in teaching and non-academic tracks (OPTIONS) are built into the curriculum requirements and graduates pursue diverse research careers including academic faculty (20%), industry (31%), physician scientists (19%), government (6%), business, policy or as postdoctoral fellows. Attrition rates are low (5.5%) and time to graduation has averaged 5.7 years. In summary, CMM has the experience, resources and talent to innovate in graduate education and supply the biomedical workforce with Ph.D. graduates rigorously trained to meet current and future needs.

项目概要/摘要 细胞和分子医学（CMM）培训计划的使命是培养博士学位。科学家为 细胞和分子水平上的实验室研究直接影响理解， 人类疾病的诊断、治疗和预防。通过一系列量身定制的课程，小团体 讨论、个性化临床暴露和实验室研究、博士学位。该计划的候选人将 接受严格的科学研究培训和对人类生物学和人类的全面了解 疾病。与对转化研究的重视一致，大多数 CMM 教师在临床环境中工作， 分布于约翰·霍普金斯大学医学院内的 22 个临床和基础科学系以及 4 个研究所 医学院和公共卫生学院。培训师将接受导师培训并经过严格评估 根据绩效标准、指导能力和项目契合度。目前项目规模为 121 名教职员工 115 名学生通过积极的导师招募、更新和指导流程，保持约 1:1 的师生比例 人员流动，以确保博士的最佳培养环境。候选人。全面审查录取20-24名学员 来自大约 150 名符合培训补助金资格的候选者的强大池规模，最近增加了 40% 在基于证据的决定取消 GRE 后，代表性不足的少数族裔申请数量增加了一倍 要求。培训项目将利用机构资金支付历年学费，支持 管理和所有计划活动，并保证学员支持。第一年的课程将从 人体入门强化课程，结合了人体尸体的动手解剖， 虚拟组织学实验室、课堂和电子讲座以及学生的小组演讲。遵循基础科学 课程涵盖分子生物学、遗传学、生物化学和细胞生物学原理，并附有 三个为期 10 周的实验室轮换，这一年将以临床研究和细胞学概论结束 疾病的分子基础，涵盖人类的一系列临床和/或社会相关疾病 身体，完成一年从“书本到凳子到床边”的循环。其他特定于计划的活动将 包括拨款写作研讨会、新开发的研究严谨性和可重复性 (3R) 课程以及 在临床合作者的指导下，个性化的从工作台到床边和背部（3B）临床经验 3-4年级的导师。该计划赞助年度静修会、期刊俱乐部和学生开展的研究 进展研讨会系列。教学和非学术领域的结构化职业培训机会 （选项）已纳入课程要求，毕业生追求多样化的研究职业，包括 学术人员 (20%)、工业界 (31%)、医师科学家 (19%)、政府 (6%)、商业、政策或其他 博士后研究员。流失率很低（5.5%），平均毕业时间为 5.7 年。总之， CMM 拥有创新研究生教育并提供生物医学领域的经验、资源和人才 拥有博士学位的劳动力毕业生经过严格培训，以满足当前和未来的需求。

项目成果

Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research.

研究技术变得简单：用于免疫研究的小鼠细菌皮肤感染模型。

• 发表时间: 2020
• 作者: Youn, Christine;Archer, Nathan K;Miller, Lloyd S
• 通讯作者: Miller, Lloyd S

A seX(X/Y) Article on Marfan Syndrome.

关于马凡氏综合症的 seX(X/Y) 文章。

• 发表时间: 2020
• 影响因子: 5.4
• 作者: Anderson, Nicole K;Juzwiak, Emily E;Dietz, Harry C
• 通讯作者: Dietz, Harry C

A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.

Ca2 -ATP 酶调节乳腺癌细胞中的 E-钙粘蛋白生物合成和上皮-间质转化。

• 发表时间: 2019
• 作者: Dang, Donna K;Makena, Monish Ram;Llongueras, José P;Prasad, Hari;Ko, Myungjun;Bandral, Manuj;Rao, Rajini
• 通讯作者: Rao, Rajini

Pharmacologic Exhaustion of Suppressor Cells with Tasquinimod Enhances Bacterial Clearance during Tuberculosis.

Tasquinimod 抑制细胞的药理学耗尽可增强结核病期间的细菌清除率。

• 发表时间: 2019
• 影响因子: 24.7
• 作者: Gupta, Shashank;Krug, Stefanie;Pokkali, Supriya;Leanderson, Tomas;Isaacs, John T;Srikrishna, Geetha;Bishai, William R
• 通讯作者: Bishai, William R

Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum.

外源多胺诱导的自噬是培养血清中牛血清胺氧化酶活性的产物。

• 发表时间: 2020-07-03
• 作者: Holbert, Cassandra E;Dunworth, Matthew;Foley, Jackson R;Dunston, Tiffany T;Stewart, Tracy Murray;Casero Jr, Robert A
• 通讯作者: Casero Jr, Robert A