Transport ATPases: From Molecules to Maladies

运输ATP酶：从分子到疾病

• 批准号: 7908312
• 负责人: RAJINI RAO
• 金额: $ 0.75万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908312
• 关键词: ATP phosphohydrolase; Acid-Base Equilibrium; Antineoplastic Agents; Applications Grants; Attention; Biochemistry; Biogenesis; Catalysis; Cations; Cell membrane; Cellular biology; Chemotherapy-Oncologic Procedure; Cholesterol; Collaborations; Communicable Diseases; Computational Biology; Copper; Development; Diabetic ulcer; Disabled Persons; Discipline; Disease; Drug Transport; Drug resistance; Drug usage; Enzymes; Fellowship; Fostering; Future; Gastric ulcer; Genetic Medicine; Goals; Health; Heart Diseases; Heart failure; Hereditary Disease; Human Pathology; Human body; Immune; Ions; Lead; Life; Lipids; Liver; Malignant Neoplasms; Membrane; Mentors; Metabolic; Mitochondrial Diseases; Movement; Multi-Drug Resistance; Names; Nanotechnology; Nerve Degeneration; Occupations; Orphan; Parkinson Disease; Participant; Pharmaceutical Preparations; Pharmacology; Process; Public Health; Pump; Research; Research Personnel; Role; Scientist; Site; Sodium Chloride; Structure; Technology; Trace metal; Treatment Failure; Vesicle; Vision; Water Movements; Work; Writing; hearing impairment; member; metalloenzyme; novel strategies; posters; skin disorder; solute; symposium; trafficking

DESCRIPTION (provided by applicant): The FASEB Summer Conference entitled, "Transport ATPases: From Molecules to Maladies" will bring together approximately 150 investigators from diverse scientific disciplines, including structural and computational biology, genetics and medicine, cell biology, biochemistry and pharmacology, to discuss exciting new developments relating to ion and solute pumps from June 6-11, 2010 at Snowmass Village, CO. The goal of the conference will be the timely integration of different lines of research on this topic for a deep, mechanistic understanding of human pathologies, paving the way for new therapies and advances in nanotechnology. An impetus for the conference is the rapidly growing number of diseases associated with Transport ATPases, among them: cancer and drug resistance, heart disease, immune and infectious diseases, ulcers, diabetes, vision and hearing loss, neurodegeneration and mitochondrial diseases. Sessions will include Rotary Catalysis, Structure and Mechanism of ATPases, Membrane Dynamics and Vesicle Fusion, Orphan ATPases, Transport ATPases and Cancer, Biogenesis, turnover and trafficking of ATPases. All major classes of Transport ATPases (P, V, F and ABC-type) will be covered, ranging in substrate from cations (H+, Na+, K+, Ca2+, Cu+) to hydrophobic drugs, cholesterol and lipids. Several speakers will be junior investigators and a Young Investigator's Forum will include selected talks from poster presentations. There will be two mentoring sessions for junior investigators: Resume building and Job searches, and Writing a Fellowship or Grant application. Special attention will be given to increase diversity among participants and the conference site will be accessible to persons with disabilities. The conference will provide ample opportunities for collegial discussions, stimulate new ideas and collaborations and foster future research on these important enzymes and metabolic engines. This is the only conference that unites scientists working in disparate fields on the sole and common topic of Transport ATPases. Project Narrative Relevance of the Conference to Public Health: Transport ATPases are essential for life and good health. They work as nanomotors or metabolic engines, producing virtually all the ATP used to fuel active processes in the human body. Other members control acid-base balance, salt and water movements within, outside and across cell membranes. Still others control the movement of trace metals, like copper into metalloenzymes. In cancer, chemotherapy often leads to increased activity of drug transporting ATPases, leading to multidrug resistance and failure of treatment. Other transport ATPases are defective in a host of genetic disorders, including a form of Parkinsons, liver and skin disease, vision and hearing loss, to name a few. Some are targets of drugs used to treat heart failure and stomach ulcers. Thus, bringing together researchers who use very different approaches to study Transport ATPases will lead to a better understanding of their role in disease and offer new approaches in treatment and technology.

描述（由申请人提供）：题为“运输 ATP 酶：从分子到疾病”的 FASEB 夏季会议将汇集来自不同科学学科的约 150 名研究人员，包括结构和计算生物学、遗传学和医学、细胞生物学、生物化学和药理学、于 2010 年 6 月 6 日至 11 日在科罗拉多州斯诺马斯村讨论与离子泵和溶质泵相关的令人兴奋的新发展。会议的目标是及时整合不同的技术该主题的研究方向是为了深入、机械地理解人类病理学，为新疗法和纳米技术进步铺平道路。会议的推动力是与运输ATP酶相关的疾病数量迅速增加，其中包括：癌症和耐药性、心脏病、免疫和传染病、溃疡、糖尿病、视力和听力损失、神经变性和线粒体疾病。会议内容包括旋转催化、ATP 酶的结构和机制、膜动力学和囊泡融合、孤儿 ATP 酶、运输 ATP 酶和癌症、ATP 酶的生物发生、周转和运输。涵盖所有主要类别的转运 ATP 酶（P、V、F 和 ABC 型），底物范围从阳离子（H+、Na+、K+、Ca2+、Cu+）到疏水性药物、胆固醇和脂质。几位演讲者将是初级研究者，青年研究者论坛将包括从海报演示中精选的演讲。将为初级研究人员提供两次指导课程：简历制作和求职，以及撰写奖学金或资助申请。我们将特别注意增加与会者的多样性，会议场地将为残疾人士提供便利。会议将为学院讨论提供充足的机会，激发新的想法和合作，并促进对这些重要酶和代谢引擎的未来研究。这是唯一一次将不同领域的科学家联合起来讨论运输 ATP 酶这一唯一且共同主题的会议。 项目叙述 会议与公共卫生的相关性：运输ATP酶对于生命和健康至关重要。它们充当纳米马达或代谢引擎，几乎产生所有用于为人体活性过程提供能量的 ATP。其他成员控制酸碱平衡、盐和水在细胞膜内、外和跨细胞膜的运动。还有一些控制微量金属的运动，例如铜进入金属酶。在癌症中，化疗通常会导致药物转运 ATP 酶活性增加，从而导致多药耐药性和治疗失败。其他转运 ATP 酶在许多遗传性疾病中都有缺陷，包括帕金森病、肝脏和皮肤病、视力和听力损失等。有些是用于治疗心力衰竭和胃溃疡的药物的目标。因此，将使用截然不同的方法来研究转运 ATP 酶的研究人员聚集在一起，将有助于更好地了解它们在疾病中的作用，并提供新的治疗方法和技术。