Novel Approaches for Linking Air Quality Mixtures, Climate, and Human Health

将空气质量混合物、气候和人类健康联系起来的新方法

• 批准号: 8912574
• 负责人: John Lanier Pearce
• 金额: $ 24.87万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-08 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8912574
• 关键词: Address; Air; Air Pollutants; Air Pollution; Area; Award; Biological; Biostatistical Methods; Birth; Cardiovascular Diseases; Climate; Cohort Studies; Complex; Development; Doctor of Philosophy; Elderly; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Epidemiologic Methods; Epidemiologic Studies; Epidemiology; Foundations; Funding; Generations; Health; Heating; Human; Infant; Institutes; Investigation; Knowledge; Lead; Link; Lung diseases; Mentors; Meteorology; Methodology; National Institute of Environmental Health Sciences; Outcome; Phase; Positioning Attribute; Public Health; Research; Resources; Risk; Role; Scientist; Series; Staging; Statistical Methods; Technology; Temperature; Testing; Time; Training; United States Environmental Protection Agency; Universities; Variant; Work; atmospheric processes; base; career; climate change; design; epidemiology study; improved; mortality; novel strategies; pollutant; response; skills; spatiotemporal

PROJECT SUMMARY: Urban air pollution is a significant public health problem with estimated mortality impacts predominantly among infants and elderly people with pre-existing cardiovascular and respiratory disease. Research on ambient air pollution health effects has begun shifting research objectives away from the single-pollutant paradigm to a more multipollutant or mixtures perspective in order to better understand the impacts of “real world” air pollution exposures on human health. Another area that is fundamentally linked to air quality and of increasing concern for public health is climate change. During the initial K99 phase, I will work closely with mentors to develop improved statistical methodologies for assessing the effects of multipollutant exposures in epidemiological studies, a natural extension of my current postdoctoral research. I will shift focus from identifying the types of air pollutant mixtures that occur in the environment to characterizing multipollutant exposures for epidemiological research. These will be applied to two ongoing epidemiological investigations that are being conducted within the Southeastern Center for Air Pollution Epidemiology (SCAPE); a US EPA funded Clean Air Research Center (CLARC, R834799) shared between Emory University and Georgia Institute of Technology: a short-term ecological study and a long-term cohort study. During the mentored phase, I will develop multipollutant temporal profiles for the investigation of short-term associations with multipollutant exposure and cardiorespiratory health outcomes. Next, I will develop multipollutant spatial profiles for the investigation of long-term associations between multipollutant exposure and the development of respiratory disease. During this phase, I will also receive new training in biostatistical and epidemiologic methods focused on environmental epidemiology at Emory University. Transitioning to independence in the R00 phase of the award, I will merge these new skills with my PhD training as I pursue research focused on understanding the implications of climate on air quality mixtures. My first independent aim will examine the meteorological sensitivity of specific multipollutant combinations in order to better understand potential changes in air pollutant mixtures under various climate scenarios. The final proposed aim is to develop environmental profiles for the examination of human health vulnerability to heat and multipollutant mixtures. At the conclusion of this award, I will have demonstrated expertise in analyzing effects for the emerging research areas of multipollutant mixtures and climate variability, providing a firm basis for my career as an environmental health scientist focusing on exposure characterizations for epidemiological research.

项目摘要：城市空气污染是一个严重的公共卫生问题，估计死亡率很高 主要对患有心血管和呼吸系统疾病的婴儿和老年人产生影响 关于环境空气污染对健康的影响的研究已经开始将研究目标从其他方面转移。 从单一污染物范式到更多污染物或混合物的视角，以便更好地理解 “现实世界”空气污染暴露对人类健康的影响是与空气根本相关的另一个领域。 在最初的 K99 阶段，我将工作。 与导师密切合作，开发改进的统计方法来评估多污染物的影响 流行病学研究的接触，这是我当前博士后研究的自然延伸，我将转移焦点。 从识别环境中出现的空气污染物混合物的类型到表征多污染物 流行病学研究的暴露将应用于两项正在进行的流行病学调查。 正在美国环保署东南空气污染流行病学中心 (SCAPE) 内进行； 埃默里大学和佐治亚学院共同资助的清洁空气研究中心（CLARC，R834799） 技术的：短期生态研究和长期队列研究在指导阶段，我会。 开发多污染物时间剖面以调查与多污染物的短期关联 接下来，我将开发多污染物空间概况。 多污染物暴露与呼吸道疾病发生之间的长期关联性调查 在此阶段，我还将接受以生物统计学和流行病学方法为重点的新培训。 埃默里大学环境流行病学博士，在 R00 阶段过渡到独立。 获奖后，我将把这些新技能与我的博士训练结合起来，因为我从事的研究重点是理解 我的第一个独立目标是研究气象对空气质量混合物的影响。 特定多污染物组合的敏感性，以便更好地了解空气污染物的潜在变化 最终提出的目标是制定各种气候情景下的混合物的环境概况。 检查人类健康对热和多污染物混合物的脆弱性。 将具有分析多污染物新兴研究领域影响的专业知识 混合物和气候变化，为我作为环境健康科学家的职业生涯奠定了坚实的基础 重点关注流行病学研究的暴露特征。