Developmental Control of the Cell Cycle

细胞周期的发育控制

基本信息

批准号：
8081156
负责人：
Robert J Duronio
金额：
$ 14.8万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-02 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8081156
关键词：
Acceleration Address Adult Affect Animals Apoptosis Binding Biological Biology Cell Cycle Cell Cycle Arrest Cell Cycle Progression Cell Cycle Regulation Cell Proliferation Cells Cyclin-Dependent Kinases Cyclins DNA Binding DNA biosynthesis DNA replication origin Development Diploid Cells Disease Drosophila genus E2F Transcription Factor 1 E2F1 gene Embryo Embryonic Development Event Failure Family G1 Arrest G1 Phase Gene Amplification Gene Expression Gene Targeting Genes Genetic Transcription Genome Growth Malignant Neoplasms Mediating Mitosis Modeling Molecular Normal Cell Organism Ovarian Follicle Pathway interactions Phase Phenotype Play Polyploidy Process Proliferating Proteins Proteolysis Regulation Retinoblastoma Role Series Signal Transduction Staging Stem Cell Development Stimulus Testing Tissues Transactivation Transcription Coactivator Tumor Suppression Tumor Suppressor Proteins Variant member mutant novel paralogous gene programs response transcription factor tumorigenesis ubiquitin ligase ubiquitin-protein ligase

项目摘要

Project Summary Determining the mechanisms of normal cell cycle control is critical for our understanding of both development and oncogenesis. During development, cell proliferation occurs by coordinating progress through the cell cycle with growth. Conversely, cell cycle arrest occurs prior to, and is often necessary for, terminal differentiation. Cell proliferation and cell cycle arrest are also highly regulated after the completion of development: stem cells in adult tissues are under tight cell cycle control, as are quiescent cells that only proliferate in response to particular stimuli. Breakdowns in cell cycle control in any of these circumstances can have drastic consequences and contribute to the deregulated growth typical of cancer. The long term objective of this project is to elucidate how developmental programs affect cell cycle progression, a process that remains poorly understood. In this proposal we focus on gene expression mechanisms that control the G1-S transition because this is when most cells decide whether to enter or to exit the cell cycle.

项目概要确定正常细胞周期控制的机制对于我们的理解至关重要发育和肿瘤发生。在发育过程中，细胞增殖是通过协调细胞周期的进展与生长。相反，细胞周期停滞发生在终末分化之前，并且通常是终末分化所必需的。细胞增殖和细胞周期停滞在发育完成后也受到高度调控：干细胞成体组织中的细胞受到严格的细胞周期控制，静态细胞也是如此因特定刺激而增殖。任何细胞周期控制的破坏这些情况可能会产生严重后果并导致放松管制癌症的典型生长。该项目的长期目标是阐明如何发育程序影响细胞周期进程，这一过程仍然很差明白了。在这个提案中，我们重点关注控制基因表达的机制 G1-S 转变，因为这是大多数细胞决定是否进入或退出细胞的时间循环。