2010 Post-Transcriptional Gene Regulation Biology of Gordon Research Conference

2010戈登研究会议转录后基因调控生物学

• 批准号: 7903519
• 负责人: Lynne E Maquat
• 金额: $ 3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-09 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903519
• 关键词: Address; Area; Biogenesis; Biology; Catalysis; Coupling; Defect; Disease; Evolution; Fertilization; Functional RNA; Functional disorder; Gene Expression Regulation; Generations; Genetic Transcription; Genomics; Goals; Health; Hereditary Disease; Human Genetics; Human Genome; Immunoprecipitation; Learning; Malignant Neoplasms; Mediating; Messenger RNA; Metabolism; MicroRNAs; Neurologic; Neuromuscular Diseases; Ointments; Participant; Postdoctoral Fellow; Principal Investigator; Public Health; RNA; RNA Processing; RNA Splicing; RNA Transport; RNA-Binding Proteins; RNA-Protein Interaction; Regulation; Request for Proposals; Research; Research Personnel; Rhode Island; Series; Signal Transduction; Site; Transfer RNA; Translations; Universities; graduate student; improved; interest; mRNA Decay; meetings; posters; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): This proposal requests partial support for a Gordon Research Conference (GRC) on The Biology of Post- Transcriptional Gene Regulation, to be held at Salve Regina University in Newport, Rhode Island, from July 18th to July 23rd, 2010. This GRC is the fourth of a series that has been held every other year since 2004. The broad and long-term goal of the Conference is to improve our current understanding of fundamental mechanisms and regulation of RNA biogenesis in normal and disease states. The emphasis is on post- transcriptional transactions involving the generation and metabolism of mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and non-coding (e.g., micro) RNAs. The Specific Aims of this meeting will be to convene approximately 45 internationally known speakers representing key areas of post-transcriptional gene regulation, with a total of 150 participants, for a five-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: coupling between transcription and RNA processing; genomics and evolution of RNA- processing signals and factors (including defining sites that are targets for RNA-binding proteins normally and in disease using immunoprecipitation followed by microarrays or high-throughput sequencing); RNA splicing catalysis, fidelity, regulation, and involvement in disease; RNA turnover, including nonsense-mediated mRNA decay; RNA transport and localization; non-coding RNA; translational control; and RNA-protein interactions. In addition, small poster sessions on four late afternoons will enable all participants to contribute to, and learn about, these topics. Free early-afternoon and late-evening periods in the relatively isolated summer setting of Salve Regina University will stimulate productive, informal discussions among established and junior principal investigators, post-doctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this GRC has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. The resulting discussions and cross- fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. 1 PUBLIC HEALTH RELEVANCE: The relevance of this application to public health reflects the extensive involvement of defects in RNA metabolism associated with many human genetic diseases, neurological and neuromuscular disorders, and cancer. In addition, elucidating genomic networks as well as the basic mechanisms of the steps of gene regulation, which are the focus of this conference, will be essential to gain a full understanding of the organization, function, and evolution of the human genome.

描述（由申请人提供）：本提案请求部分支持将于 7 月 18 日至 23 日在罗德岛州纽波特的 Salve Regina 大学举行的关于转录后基因调控生物学的戈登研究会议 (GRC)， 2010 年。本次 GRC 是自 2004 年以来每隔一年举行一次的系列会议中的第四次。会议的广泛和长期目标是提高我们目前对基本机制和正常和疾病状态下 RNA 生物发生的调节。重点是涉及 mRNA 生成和代谢的转录后事务，但这还扩展到转录耦合以及参与翻译及其控制的因素，包括 tRNA 和非编码（例如微）RNA。本次会议的具体目标是召集约 45 位代表转录后基因调控关键领域的国际知名演讲者，总共 150 名与会者，举行为期五天的会议。该计划将包括九场上午或晚上的会议，将广泛解决以下领域的前沿问题：转录和 RNA 处理之间的耦合； RNA处理信号和因子的基因组学和进化（包括使用免疫沉淀和微阵列或高通量测序来定义正常和疾病中RNA结合蛋白的靶位点）； RNA剪接催化、保真度、调节和参与疾病； RNA 周转，包括无义介导的 mRNA 衰减； RNA运输和定位；非编码RNA；平移控制；以及RNA-蛋白质相互作用。此外，四个下午晚些时候举行的小型海报会议将使所有参与者能够对这些主题做出贡献并了解这些主题。在萨尔维里贾纳大学相对偏僻的夏季环境中，下午早些时候和晚上的空闲时间将刺激来自美国和国外的资深和初级首席研究员、博士后实习生和研究生之间进行富有成效的非正式讨论。该应用程序的重要性在于，该 GRC 具有独特的格式，并将多组研究人员聚集在一起，尽管他们有共同的兴趣，但很少有机会作为一个群体见面。由此产生的讨论和交叉融合将有助于确定推动该领域向前发展的关键领域。此外，阐明转录后基因调控的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。该应用的健康相关性反映了RNA加工功能障碍在许多遗传疾病、神经和神经肌肉疾病以及癌症中的广泛参与。 1 公共健康相关性：该应用与公共健康的相关性反映了与许多人类遗传疾病、神经和神经肌肉疾病以及癌症相关的 RNA 代谢缺陷的广泛参与。此外，阐明基因组网络以及基因调控步骤的基本机制是本次会议的重点，这对于全面了解人类基因组的组织、功能和进化至关重要。