Training in Cellular, Biochemical and Molecular Sciences

细胞、生化和分子科学培训

• 批准号: 8092843
• 负责人: Lynne E Maquat
• 金额: $ 26.51万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8092843
• 关键词: Biochemical; Molecular; Science; Training

DESCRIPTION (provided by applicant): We describe the continuation of a pre-doctoral training program in Cellular, Biochemical and Molecular Biology (http://dbb.urmc.rochester.edu/T32/index.htm) with a core of interactive investigators in RNA, DNA, and protein biochemistry. The proposed training program capitalizes on (i) initiatives that expand research and education at the University of Rochester Medical Center (URMC) and College of Arts and Sciences (CAS), and (ii) enhanced educational choices resulting from the successful reorganization of Graduate Education in Biomedical Sciences (GEBS). Students are accepted into multidisciplinary "Clusters". They experience diverse research areas in their first year through courses, faculty research presentations, and laboratory rotations. They then choose a research advisor and degree program from a wide range of opportunities. We will maintain successful T32 initiatives: 1) provide one year of financial support for 6-8 students performing interdisciplinary research; 2) promote direct interactions between students and visiting seminar speakers; 3) offer practice in critical thinking in research science; 4) provide opportunities for off-site student travel to attend meetings, take courses, and work in outside laboratories; 5) counsel female and minority students to achieve career goals; 6) foster interactions among investigators and students in the areas of RNA, DNA, and protein biochemistry through course requirements and a yearly retreat; and 7) augment effective student recruiting through training-grant educational benefits. The University is benefiting from the recent appointments of a new President and Medical Center Director. Since funding of this T32, the URMC has not only filled two new research facilities (400,000 sq. ft.) and started new programs in Genetics, Biochemistry, Structural Biology, Virology, Signaling, Immunology, Neurobiology and Stem Cells, increasing the number of PIs from 150 to about 250, but also initiated a Strategic Plan with the construction of 500,000 sq. ft. of new labs. The Strategic Plan includes creation of five Innovative Science Programs that increase the opportunities for graduate training. Within this expanding infrastructure, our T32 continues to promote interactions among labs, flexibility in the choice of research mentors, and improved graduate recruiting. PUBLIC HEALTH RELEVANCE: Research funded by this T32 pertains to cellular, biochemical and molecular biology, with a focus on the structure and function of DNA, RNA and proteins. In view of the recent appreciation that most of genomic DNA is transcribed into RNA and that many genes encode more than one protein, research supported by this T32 will lend important insight into the mechanisms of cellular maintenance, growth and differentiation.

描述（由申请人提供）：我们描述了以互动研究人员为核心的细胞、生物化学和分子生物学博士前培训计划的延续（http://dbb.urmc.rochester.edu/T32/index.htm） RNA、DNA 和蛋白质生物化学。拟议的培训计划利用了 (i) 扩大罗切斯特大学医学中心 (URMC) 和艺术与科学学院 (CAS) 研究和教育的举措，以及 (ii) 研究生教育的成功重组带来的更多教育选择生物医学科学（GEBS）。学生被接纳进入多学科“集群”。他们在第一年通过课程、教师研究报告和实验室轮换体验不同的研究领域。然后，他们从广泛的机会中选择研究顾问和学位课程。我们将保持成功的 T32 举措：1）为 6-8 名进行跨学科研究的学生提供一年的财政支持； 2）促进学生和来访研讨会演讲者之间的直接互动； 3）提供研究科学批判性思维的实践； 4）为学生提供异地出差参加会议、参加课程以及在外部实验室工作的机会； 5) 为女性和少数民族学生提供实现职业目标的咨询； 6) 通过课程要求和年度静修活动，促进 RNA、DNA 和蛋白质生物化学领域研究人员和学生之间的互动； 7) 通过培训补助金教育福利来提高招生效率。最近任命的新校长和医疗中心主任使该大学受益匪浅。自从 T32 获得资助以来，URMC 不仅填补了两个新的研究设施（400,000 平方英尺），还启动了遗传学、生物化学、结构生物学、病毒学、信号传导、免疫学、神经生物学和干细胞的新项目，增加了PI 从 150 名增加到约 250 名，同时还启动了一项战略计划，建设 500,000 平方英尺的新实验室。该战略计划包括创建五个创新科学项目，以增加研究生培训的机会。在这个不断扩大的基础设施中，我们的 T32 继续促进实验室之间的互动、研究导师选择的灵活性以及改进的毕业生招聘。 公共健康相关性：该 T32 资助的研究涉及细胞、生化和分子生物学，重点是 DNA、RNA 和蛋白质的结构和功能。鉴于最近认识到大多数基因组 DNA 都会转录成 RNA，并且许多基因编码不止一种蛋白质，T32 支持的研究将为细胞维持、生长和分化的机制提供重要的见解。