Impact of Maternal Methamphetamine Abuse on Neonatal Immunity

母亲滥用甲基苯丙胺对新生儿免疫力的影响

基本信息

批准号：
8045879
负责人：
Luis R Martinez
金额：
$ 11.97万
依托单位：
LONG ISLAND UNIVERSITY C. W. POST CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-21 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8045879
关键词：
Adult Affect Award Behavior Blood - brain barrier anatomy Candida albicans Cells Central Nervous System Infections Central Nervous System Stimulants Cognitive Communicable Diseases Cryptococcus neoformans Defect Development Drug abuse Drug usage Exposure to Female of child bearing age Fetus Foundations Future Goals Immune Immune system Immunity Investigation Knowledge Methamphetamine Molecular Mothers Mus Natural Immunity Neonatal Neuraxis Pathway interactions Pharmaceutical Preparations Placenta Population Predisposition Pregnancy Pregnant Women Public Health Research Risk Role Scourge Societies design drug of abuse fetal methamphetamine exposure fungus high risk in utero in vivo Model innate immune function maternal methamphetamine abuse maternal methamphetamine use methamphetamine abuse microbial mouse model neonate offspring pathogen prenatal exposure programs response tissue culture

项目摘要

DESCRIPTION (provided by applicant): Methamphetamine (METH) is a major drug of abuse in the USA and the world. Furthermore, METH abuse by females of child-bearing age has become a significant public health concern in terms of potential short and long-term risks to an exposed fetus. In pregnancy, METH can cross the placenta and reach the fetus. My program is designed to make major advances in our understanding of how the innate immune system of neonates is affected at the molecular and cellular levels by maternal METH abuse. Although there is substantial information on the physical and cognitive defects caused by METH in offspring exposed to the drug during pregnancy there is a dearth of knowledge regarding its impact on innate immunity. I have previously shown that METH alters the capacity of the adult host to effectively respond to microbial challenges and I hypothesize that neonates exposed to METH in utero will have further defects in innate immunity. There are two AIMS proposed: (1) to determine whether offspring exposed to METH during pregnancy have defective innate immunity; and (2) to assess the effect of METH on the integrity of the BBB of exposed neonates in response to microbial challenge. I believe this project is of considerable significance in the fields of immunity, host-pathogen interactions and drug abuse. I anticipate that understanding the relationship between these fields may help to develop more effective public health strategies to deal with this scourge on our society. Methamphetamine is a major scourge on our society. The drug adversely changes people's behavior, including putting users at high risk for the acquisition of diverse infectious diseases. Unfortunately, pregnant women comprise an important population using methamphetamine. There is very little information on the effects of the drug use on the offspring of methamphetamine abusing mothers. Using mouse models of abuse, my program will define the impact of maternal methamphetamine use on the function of specific cells of the innate immune system and the cells that comprise the blood brain barrier of neonates.

描述（由申请人提供）：甲基苯丙胺 (METH) 是美国和世界各地滥用的主要药物。此外，育龄女性滥用冰毒已成为一个重大的公共卫生问题，因为它对胎儿造成短期和长期的潜在风险。在怀孕期间，冰毒可以穿过胎盘并到达胎儿。我的项目旨在加深我们对母亲滥用冰毒如何在分子和细胞水平上影响新生儿先天免疫系统的理解。尽管有大量关于妊娠期间接触该药物的后代因冰毒引起的身体和认知缺陷的信息，但对其对先天免疫的影响仍知之甚少。我之前已经证明，冰毒会改变成年宿主有效应对微生物挑战的能力，我假设在子宫内接触冰毒的新生儿在先天免疫方面会出现进一步的缺陷。提出的目标有两个：（1）确定妊娠期间接触冰毒的后代是否存在先天免疫缺陷； (2) 评估冰毒对暴露的新生儿血脑屏障完整性的影响，以应对微生物挑战。我相信这个项目在免疫、宿主-病原体相互作用和药物滥用等领域具有重要意义。我预计，了解这些领域之间的关系可能有助于制定更有效的公共卫生策略来应对我们社会的这一祸害。甲基苯丙胺是我们社会的一大祸害。该药物会对人们的行为产生不利影响，包括使使用者面临感染多种传染病的高风险。不幸的是，孕妇是使用甲基苯丙胺的重要人群。关于吸毒对甲基苯丙胺滥用母亲的后代的影响的信息很少。使用虐待小鼠模型，我的计划将确定母亲使用甲基苯丙胺对先天免疫系统特定细胞和构成新生儿血脑屏障的细胞功能的影响。