West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health

西弗吉尼亚州临床和转化科学研究所：全州范围内的组织，致力于打造卓越研究并吸引社区改善健康

• 批准号: 10876642
• 负责人: Sally Lynn Hodder
• 金额: $ 7.16万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10876642
• 关键词: 2019-nCoV; Academic Medical Centers; Acceleration; Address; Alzheimer' s Disease; Appalachian Region; Award; COVID-19 pandemic; COVID-19 patient; Cardiovascular Diseases; Categories; Chronic Disease; Chronic lung disease; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Collaborations; Color; Communication; Communities; Community Outreach; County; Development; Environmental Hazards; Exposure to; Funding; Goals; Grant; HIV; Health; Health Resources; Human; Human Resources; Incidence; Institution; Lead; Leadership; Life Expectancy; Malignant Neoplasms; Medical center; National Institute for Occupational Safety and Health; Osteopathic Medicine; Outcome; Policies; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Primary Care; Productivity; Public Health; Publications; Registries; Research; Research Infrastructure; Research Personnel; Rural Community; Rural Health; Rural Population; Science; Scientist; Site; Substance Use Disorder; Testing; Training; Translational Research; Trust; United States; United States Department of Veterans Affairs; United States National Institutes of Health; West Virginia; Work; addiction; cohort; community engagement; coronavirus disease; equity, diversity, and inclusion; health care service organization; health disparity; improved; medical schools; mortality; new epidemic; next generation; practice-based research network; predictive modeling; programs; reproductive; substance use; success; translational scientist

West Virginia (WV), the only state located entirely in Appalachia, has the lowest life expectancy in the nation and ranks at or near the bottom in many chronic disease categories. The WV Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Institutional Development Award for Clinical and Translational Research (IDeA-CTR) and successfully renewed in 2017. Over the past 9 years, WVCTSI has cultivated and nurtured a highly collaborative, statewide research infrastructure to address the substantial health disparities in WV. Over the past 4 years, WVCTSI productivity has been superb with 1,325 publications, 951 funding applications, and 688 external funding awards totaling $159.3 MM. The WVCTSI’s overarching goal for the next funding cycle is to serve as a transformational force, leading statewide clinical and translational collaborative research that positively impacts health outcomes in WV. We will achieve this goal through the following specific aims: Specific Aim 1 - Build collaborative, productive research infrastructure across WV that substantively contributes to improving WV health outcomes, Specific Aim 2 - Train and position for success the next generation of clinical and translational scientists, and Specific Aim 3 - Actively engage multiple stakeholders, including rural communities, in research and effectively disseminate research results to rural populations in a manner that facilitates understanding and trust. There are 3 important cross-cutting themes around which our efforts will be focused that include: 1) Rural Health, 2) Diversity, Equity, and Inclusion (engaging not only WV’s rural communities but also WV’s communities of color; equally important is supporting diverse investigators), and 3) the clinician scientists of tomorrow – able to frame the right questions and work to find the answers. Central to attainment of our specific aims is the highly collaborative statewide organization that WVCTSI has developed over the preceding 9 years and that now includes every major healthcare organization and academic medical center in WV, the state health department (WVDHHR), the National Institute for Occupational Safety and Health, and >100 primary care organizations across WV that constitute the WV Practice-Based Research Network. Equally important is the high level of collaboration and commitment among WVCTSI’s cores. Successful completion of our objectives will inform policy, practice, and community changes resulting in improved WV health outcomes.

西弗吉尼亚州 (WV) 是唯一完全位于阿巴拉契亚的州，其预期寿命是全美最低的。 在许多慢性疾病类别中排名垫底或接近垫底。 转化科学研究所 (WVCTSI) 成立于 2012 年，通过最初的机构 临床和转化研究发展奖（IDeA-CTR）并于2017年成功续展 2017 年。在过去的 9 年里，WVCTSI 培养和培养了一个高度协作的联邦机构 解决西弗吉尼亚州巨大健康差异的研究基础设施 在过去 4 年中， WVCTSI 的生产力非常出色，共发布了 1,325 份出版物、951 份资助申请和 688 份申请。 WVCTSI 下一次融资的总体目标为 159.3 MM 美元的外部资助。 循环是作为变革力量，引领司法临床和转化协作 对西弗吉尼亚州健康结果产生积极影响的研究 我们将通过以下方式实现这一目标。 具体目标：具体目标 1 - 在西弗吉尼亚州建立协作、高效的研究基础设施， 为改善西弗吉尼亚州的健康结果做出实质性贡献，具体目标 2 - 培训和定位 下一代临床和转化科学家的成功，以及具体目标 3 - 积极参与 包括农村社区在内的多个利益相关者参与研究并有效传播研究成果 以促进理解和信任的方式向农村人口提供成果有 3 个重要方面。 我们的工作重点围绕跨领域主题，包括：1) 农村卫生，2) 多样性， 公平和包容（不仅让西弗吉尼亚州的农村社区参与，还让西弗吉尼亚州的有色人种社区参与； 同样重要的是支持不同的研究人员），以及 3）未来的临床科学家 – 有能力 提出正确的问题并努力寻找答案对于实现我们的具体目标至关重要。 是 WVCTSI 在过去 9 年来发展起来的高度协作的全州组织 多年来，现在包括西弗吉尼亚州的每个主要医疗保健组织和学术医疗中心， 州卫生部门 (WVDHHR)、国家职业安全与健康研究所，以及 西弗吉尼亚州超过 100 个初级保健组织构成了西弗吉尼亚州基于实践的研究网络。 同样重要的是 WVCTSI 核心之间的高水平协作和承诺。 成功完成我们的目标将为政策、实践和社区变化提供信息 改善西弗吉尼亚州的健康结果。

项目成果

Variations in Hepatitis B Vaccine Series Completion by Setting Among Adults at Risk in West Virginia.

西弗吉尼亚州高危成年人中乙型肝炎疫苗系列完成情况的差异。

• 发表时间: 2020
• 影响因子: 5.5
• 作者: Tressler, Stacy;Lilly, Christa;Gross, Diane;Hulsey, Thomas;Feinberg, Judith
• 通讯作者: Feinberg, Judith

Characteristics of Fatal, Pedestrian-Involved, Motor Vehicle Crashes in West Virginia: A Cross-Sectional and Spatial Analysis.

西弗吉尼亚州涉及行人的致命机动车辆事故的特征：横截面和空间分析。

• 发表时间: 2023-03-24
• 作者: Rudisill, Toni M;Barbee, Lauren Olivia;Hendricks, Brian
• 通讯作者: Hendricks, Brian

Stay and play or load and go? The association of on-scene advanced life support interventions with return of spontaneous circulation following traumatic cardiac arrest.

留下来玩还是加载然后走？

• 发表时间: 2023-10
• 作者: Smida, Tanner;Price, Bradley S;Scheidler, James;Crowe, Remle;Wilson, Alison;Bardes, James
• 通讯作者: Bardes, James

Acute exposure to artificial light at night alters hippocampal vascular structure in mice.

夜间急性暴露于人造光会改变小鼠海马血管结构。

• 发表时间: 2023-07-21
• 影响因子: 5.8
• 作者: Bumgarner, Jacob R;Walker 2nd, William H;Quintana, Dominic D;White, Rhett C;Richmond, Alexandra A;Meléndez;Liu, Jennifer A;Becker;Walton, James C;Simpkins, James W;DeVries, A Courtney;Nelson, Randy J
• 通讯作者: Nelson, Randy J

Comparing the effects of decreasing prescription opioid shipments and the release of an abuse deterrent OxyContin formulation on opioid overdose fatalities in WV: an interrupted time series study.

比较减少处方阿片类药物运输和释放滥用威慑奥施康定制剂对西弗吉尼亚州阿片类药物过量死亡的影响：一项间断时间序列研究。

• 发表时间: 2024-01-04
• 作者: Lundstrom, Eric W;Dai, Zheng;Groth, Caroline P;Hendricks, Brian;Winstanley, Erin L;Abate, Marie;Smith, Gordon S
• 通讯作者: Smith, Gordon S