West Virginia Clinical and Translational Science Institute: Improving Health through Partnerships and Transformative Research

西弗吉尼亚临床和转化科学研究所：通过合作伙伴关系和变革性研究改善健康

• 批准号: 10004059
• 负责人: Sally Lynn Hodder
• 金额: $ 400万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004059
• 关键词: Academic Medical Centers; Address; Americas; Appalachian Region; Area; Award; Cardiovascular Diseases; Cardiovascular system; Categories; Chronic Disease; Chronic lung disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Computerized Medical Record; Development; Epidemic; Funding; Future; Goals; Health; Health Priorities; Hepatitis C; Hospital Administration; Human; Individual; Infrastructure; Institutes; Investments; Kentucky; Lead; Malignant Neoplasms; Medical; Mentors; Modeling; National Institute for Occupational Safety and Health; Outcome; Overdose; Patient Recruitments; Pharmaceutical Preparations; Pilot Projects; Play; Policies; Policy Maker; Positioning Attribute; Productivity; Provider; Publications; Research; Research Infrastructure; Research Personnel; Role; Rural; Rural Community; Rural Population; Science; Scientist; Services; Site; Syndrome; Training; Training Support; Translational Research; Trust; United States; United States Department of Veterans Affairs; Universities; West Virginia; Work; addiction; base; commercialization; data warehouse; health disparity; improved; innovation; interdisciplinary approach; mortality; new technology; next generation; practice-based research network; recruit; success; translational scientist; trend

Mortality rates in Appalachia have progressively increased over recent years, in contrast to decreasing mortality rates observed in the remainder of the US. West Virginia was ranked 47th overall among the 50 states in the 2015 America's Health Rankings. In addition, WV remains at, or near, the bottom for a number of chronic diseases including cancer and cardiovascular disease. These observations alone do not capture the entire continuum of health related challenges in the state or region, but clearly emphasize the need for continued focus on, and investment in, research that underpins real solutions. The West Virginia Clinical and Translational Science Institute (WVCTSI) was created in 2012 through the initial Clinical and Translational Research (CTR) award and has subsequently formed a well-connected, statewide research network, creating the infrastructure to address the substantial health disparities that exist in West Virginia. The overarching goal of the WVCTSI is to serve as a collaborative hub to lead statewide innovation in clinical and translational research, catalyzing and accelerating development of solutions to vexing health problems. Over the past four years, WVCTSI has been a transformative force, implementing investigator mentoring services, establishing pilot project funding, forming a practice-based research network of 68 sites (mostly rural), creating an integrated data repository of two million unique electronic medical records, developing a broad-based culture of research integrity, and working with our partners to establish trust and effective collaboration. WVCTSI is now well positioned to attain the goals of this renewal application that include: 1) building sustainable research infrastructure that substantively contributes to improving WV health outcomes by 2022, 2) recruiting the next generation of clinician scientists and translational researchers that excel in team science and are positioned for long-term success, and 3) actively engaging with multiple stakeholders that include communities, medical providers, and policy makers to drive research that improves health of West Virginians. Our partners include all academic medical centers within the state as well as the University of Kentucky, the Veterans Administration, and the National Institute for Occupational Safety and Health. Through its collective activities and powerful partnerships, the WVCTSI will play a critical role in reversing the trend of increasing mortality rates in West Virginia and serve as a model for developing effective research infrastructure that provides solutions to regional health issues.

近年来，阿巴拉契亚地区的死亡率逐渐上升，而死亡率却不断下降 美国其他地区观察到的比率。西弗吉尼亚州在 50 个州中总体排名第 47 位 2015年美国健康排名。此外，西弗吉尼亚州仍然处于或接近一些慢性疾病的底部。 疾病包括癌症和心血管疾病。仅凭这些观察并不能涵盖全部 国家或地区持续面临与健康相关的挑战，但明确强调需要持续关注 对支持真正解决方案的研究进行投资。西弗吉尼亚州临床和转化 科学研究所 (WVCTSI) 成立于 2012 年，通过最初的临床和转化研究 (CTR) 奖项，并随后形成了一个联系良好的全州研究网络，创建了基础设施 解决西弗吉尼亚州存在的巨大健康差距。 WVCTSI 的总体目标是 作为一个协作中心，领导全州范围内的临床和转化研究创新，促进和 加快制定解决棘手健康问题的方案。在过去的四年里，WVCTSI 一直 变革力量，实施研究者指导服务，建立试点项目资金，形成 由 68 个地点（大部分是农村）组成的基于实践的研究网络，创建了一个包含 200 万个数据的综合数据存储库 独特的电子病历，发展基础广泛的研究诚信文化，并与我们合作 合作伙伴建立信任和有效的协作。 WVCTSI 现在已做好充分准备来实现这一目标 更新申请包括：1）建设可持续的研究基础设施，为 到 2022 年改善西弗吉尼亚州的健康状况，2) 招募下一代临床科学家和转化人员 擅长团队科学并能够取得长期成功的研究人员，以及 3) 积极参与 包括社区、医疗服务提供者和政策制定者在内的多个利益相关者共同推动研究 改善西弗吉尼亚人的健康。我们的合作伙伴还包括州内的所有学术医疗中心 肯塔基大学、退伍军人管理局和国家职业安全研究所 和健康。通过其集体活动和强大的伙伴关系，WVCTSI 将在以下领域发挥关键作用： 扭转西弗吉尼亚州死亡率上升的趋势，并成为制定有效的 为区域健康问题提供解决方案的研究基础设施。