Mechanisms for Activation of Beige Adipose Tissue in Humans; Supplement

人类米色脂肪组织的激活机制；

• 批准号: 10630687
• 负责人: Philip A Kern
• 金额: $ 47.25万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630687
• 关键词: Academic Medical Centers; Address; Adipose tissue; Adult; Americas; Area; Autoantibodies; Autoimmunity; Beta Cell; Body mass index; C-Peptide; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 severity; Caring; Child; Childhood; Clinical; Clinical Data; Code; Communities; Data; Data Analyses; Data Set; Data Sources; Databases; Development; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis; Electronic Health Record; Endocrinologist; Epidemiologist; Epidemiology; Ethnic Origin; Glucocorticoids; Glycosylated hemoglobin A; Health; Healthcare; High Prevalence; Human; Incidence; Individual; Infection; Inflammation; Inflammatory; Inpatients; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Kentucky; Laboratories; Link; Lung; Medicaid; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outpatients; Patients; Persons; Pharmaceutical Preparations; Population; Process; Race; Registries; Reporting; Resources; Retrospective cohort; Risk; Rural; SARS-CoV-2 infection; Severities; Severity of illness; Test Result; United States; Universities; Vaccination; Vaccines; Vital Statistics; autoimmune pathogenesis; beneficiary; clinically relevant; coronavirus disease; design; diabetogenic; health disparity; high risk; improved; marginalized population; post SARS-CoV-2 infection; response; severe COVID-19; sociodemographics; socioeconomic disadvantage; study population; trend; vaccine acceptance

Abstract This proposal is a supplement to “Mechanisms for Activation of Beige Adipose Tissue in Humans”, R01 DK124626 in response to NOT-DK-22-017. The supplement is titled: “Impact of COVID-19 on diabetes incidence and severity in the United States and Kentucky”. There is mounting evidence that COVID-19 is associated with increased risk of incident diabetes. This supplement assembles a team of Endocrinologists, Pulmonary intensivists, Informaticians, Epidemiologists and Statisticians who will perform a detailed analysis of linked comprehensive data sets to identify key factors (and putative mechanisms) that relate COVID-19 infection to incident diabetes. In the proposed project, the team will explore the COVID and incident diabetes relationship among adults and children using three distinct data sources: 1) a large, nationwide database of commercially insured individuals (MarketScan), 2) Kentucky state Medicaid claims data, and 3) detailed clinical data from the University of Kentucky HealthCare (UKHC) electronic health record (EHR). Our overall hypothesis is that new onset diabetes is greater in subjects with the most severe COVID infections and in areas of Kentucky with the health disparities. To address these hypotheses, we propose the following Specific Aims, 1) to compare population-level trends in the incidence and severity of new onset diabetes during the COVID-19 pandemic (2020-2021) to historical data (2018-2019) in three distinct study populations, and 2) to examine the association between COVID infection and incident diabetes at the individual level using a matched, retrospective cohort design. We will also examine factors that modify this association, including severity of diabetes, diabetes type, sociodemographics (age, race/ethnicity, region), BMI, severity of COVID infection, vaccination status, timing of diabetes onset following COVID-19, and overall health from diagnosis codes, lab values, medications and clinical notes. In summary, this study will examine the relationship between COVID-19 and incident diabetes in very different populations, including rural Kentucky, which has high health disparities. In addition, we will examine the effects of prior vaccination, which may lessen the severity of disease and decrease diabetes incidence.

抽象的 该提案是“人类米色脂肪组织激活机制”的补充，R01 DK124626 回应 NOT-DK-22-017 该补充的标题是：“COVID-19 对糖尿病的影响”。 美国和肯塔基州的发病率和严重程度”。 越来越多的证据表明，COVID-19 与罹患糖尿病的风险增加有关。 补充品汇集了内分泌学家、肺重症监护医师、信息学家、流行病学家和 统计学家将对关联的综合数据集进行详细分析，以确定关键因素（以及 将 COVID-19 感染与糖尿病事件联系起来的推定机制）。 将使用三个不同的数据探讨成人和儿童之间的新冠病毒与糖尿病发病率的关系 来源：1) 大型全国性商业保险个人数据库 (MarketScan)，2) 肯塔基州 医疗补助索赔数据，以及 3) 来自肯塔基大学医疗保健 (UKHC) 的详细临床数据 我们的总体假设是，患有以下疾病的受试者新发糖尿病的比例更高。 肯塔基州最严重的新冠病毒感染地区以及存在健康差异的地区。 假设，我们提出以下具体目标，1）比较人口水平的发病率趋势 COVID-19 大流行期间（2020-2021 年）新发糖尿病的严重程度与历史数据（2018-2019 年）的比较 在三个不同的研究人群中，2) 检查新冠病毒感染与事件之间的关联 我们还将使用匹配的回顾性队列设计来研究个体水平的糖尿病。 修改这种关联，包括糖尿病的严重程度、糖尿​​病类型、社会人口统计学（年龄、种族/民族、 地区）、BMI、COVID 感染的严重程度、疫苗接种状况、COVID-19 后糖尿病发病时间，以及 总之，本研究将通过诊断代码、实验室值、药物和临床记录来了解整体健康状况。 研究不同人群（包括农村人群）中的 COVID-19 与糖尿病事件之间的关系 肯塔基州的健康状况差异很大。此外，我们将检查之前接种疫苗的效果。 可以减轻疾病的严重程度并降低糖尿病的发病率。