Kentucky Center for Clinical and Translational Science

肯塔基州临床和转化科学中心

• 批准号: 10733214
• 负责人: Philip A Kern
• 金额: $ 17.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733214
• 关键词: Address; Adolescence; Adult; Age; Air Pollution; Appalachian Region; Automobile Driving; Award; Back; Body mass index; Cardiovascular system; Child; Childhood; Clinic Visits; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Collection; Communication; Communities; Community Healthcare; Development; Diabetes Mellitus; Diagnosis; Discipline; Disparity; Distress; Drowsiness; Economics; Elderly; Environment; Environmental Exposure; Environmental Pollutants; Environmental Risk Factor; Epidemic; Epidemiology; Exposure to; Fostering; Frequencies; Future; Generations; Glycosylated hemoglobin A; Goals; Hair; Health; Health Disparities Research; Health Status; Healthcare; Heavy Metals; Home; Individual; Institution; Integrated Health Care Systems; Joints; Kentucky; Lead; Leg Cramp; Letters; Life Cycle Stages; Link; Literature; Longevity; Malignant Neoplasms; Measurement; Measures; Metal exposure; Metals; Mission; Modeling; Neurosciences; Obesity; Occupational; Outcome; Outcome Study; Parasomnias; Participant; Patient Self-Report; Pediatric cohort; Persons; Phase; Population; Positioning Attribute; Prevalence; Process; Quality of life; Questionnaires; Recommendation; Recording of previous events; Reporting; Research; Role; Rural; Rural Appalachia; Rural Community; Rural Health; School-Age Population; Science; Serum; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Smoke; Smoking; Snoring; Statistical Methods; Structure of nail of toe; Substance abuse problem; Symptoms; Syndrome; Translational Research; Underserved Population; United States; Universities; Update; West Virginia; Whole Blood; Work; cardiometabolism; clinical center; cohort; community based participatory research; community engagement; deciduous tooth; diversity and inclusion; early life exposure; environmental tobacco smoke; environmental tobacco smoke exposure; health disparity; health equity; health inequalities; improved; innovation; new technology; obesity in children; obesity risk; opioid abuse; parent grant; patient engagement; poor sleep; preadolescence; programs; rural area; rural dwellers; sleep behavior; sleep health; sleep onset; social factors; urinary; web site

PARENT GRANT PROJECT SUMMARY - OVERALL The University of Kentucky (UK) Center for Clinical and Translational Science (CCTS) has created an integrated home for clinical and translational research which promotes scientific progress and discoveries at every phase of the translational continuum. The CCTS has partnered with communities in Central Appalachia to address multiple generations of recalcitrant health inequities related in part to the economic distress of rural communities. The CCTS has fundamentally transformed UK and Central Appalachia through the development of strong academic-community research networks and collaborations within the CTSA consortium. Appalachian health disparities are further magnified by the opioid and substance abuse epidemic, which has greatly impacted eastern Kentucky and West Virginia. The strong UK research portfolio puts the UK CCTS in an optimal position to lead local, regional and national research efforts focused on rural health inequities. The aligned missions of UK, UK HealthCare and the CCTS focus on achieving health equity by engaging in highly innovative, collaborative and dynamic translational research to address rural health needs. The CCTS will continue to educate the translational workforce of the future, engage rural communities in translational and bi-directional team science and work with the national network to advance transdisciplinary research and clinical trials through the following Specific Aims: 1) develop, innovate and transform our research environment to promote impactful science and discovery within our integrated health care system to meet the unique health needs of Central Appalachian residents; 2) lead institutional innovation in the delivery of impactful clinical and translational research that covers the lifespan, fully engages the community and embraces team science; 3) catalyze an efficient, university-wide clinical trials organization which adds value to the CTSA consortium by engaging participants from rural Central Appalachia; and 4) foster and enhance a workforce characterized by diversity and inclusivity across all translational science disciplines and populations. The UK CTSA hub is uniquely positioned in the National CTSA Consortium to foster novel technologies, team science, clinical trial start-up and cutting-edge translational research across the lifespan with a focus on rural communities. We have a particular focus on the Central Appalachian community, a rural area with many of the highest levels of health disparities in the nation. This focus will ultimately elevate the health and quality of life of rural communities throughout the United States.

家长补助金项目摘要 - 总体 肯塔基大学（英国）临床和转化科学中心 (CCTS) 创建了一个 临床和转化研究的综合家园，促进科学进步和发现 翻译连续体的每个阶段。 CCTS 与阿巴拉契亚中部社区合作 解决多代人顽固的健康不平等问题，部分原因是农村经济困难 社区。 CCTS 通过发展从根本上改变了英国和阿巴拉契亚中部 CTSA 联盟内强大的学术界研究网络和合作。 阿巴拉契亚地区的健康差距因阿片类药物和药物滥用的流行而进一步扩大， 极大地影响了东肯塔基州和西弗吉尼亚州。强大的英国研究组合使英国 CCTS 跻身 领导以农村卫生不平等为重点的地方、区域和国家研究工作的最佳职位。 英国、英国医疗保健和 CCTS 的一致使命侧重于通过参与实现健康公平 高度创新、协作和动态的转化研究，以满足农村卫生需求。 CCTS 将继续教育未来的转化劳动力，让农村社区参与转化和 双向团队科学并与国家网络合作推进跨学科研究和 通过以下具体目标进行临床试验：1）开发、创新和改造我们的研究环境 在我们的综合医疗保健系统中促进有影响力的科学和发现，以满足独特的健康需求 阿巴拉契亚中部居民的需求； 2）领导机构创新，提供有影响力的临床和 涵盖生命周期、充分吸引社区并拥抱团队科学的转化研究； 3） 促进建立一个高效的、大学范围内的临床试验组织，通过以下方式为 CTSA 联盟增加价值 吸引来自阿巴拉契亚中部农村地区的参与者； 4) 培养和增强一支具有以下特点的劳动力队伍 所有转化科学学科和人群的多样性和包容性。英国 CTSA 中心是 在国家 CTSA 联盟中处于独特地位，致力于促进新技术、团队科学和临床试验 整个生命周期的初创和尖端转化研究，重点关注农村社区。我们 特别关注阿巴拉契亚中部社区，该农村地区拥有许多最高水平的 全国的健康差距。这一重点最终将提高农村地区的健康和生活质量 美国各地的社区。

项目成果

Treatment Bias in Management of HIV Patients Admitted for Acute Myocardial Infarction: Does It Still Exist?

因急性心肌梗塞入院的艾滋病毒患者管理中的治疗偏差：是否仍然存在？

• 发表时间: 2020
• 影响因子: 5.7
• 作者: Ogunbayo, Gbolahan O;Ha, Le Dung;Ahmad, Qamar;Misumida, Naoki;Okwechime, Remi;Elbadawi, Ayman;Abdel;Elayi, C S;Smyth, Susan;Boccara, Franck;Messerli, Adrian W
• 通讯作者: Messerli, Adrian W

Is dyschloremia a marker of critical illness or euchloremia an interventional target to improve outcomes?

氯血症是危重疾病的标志，还是氯血症是改善预后的干预目标？

• 发表时间: 2019-12
• 作者: Canepa;Neyra, Javier A
• 通讯作者: Neyra, Javier A

Depression and Anxiety Are Associated With Increased Health Care Costs and Opioid Use for Patients With Femoroacetabular Impingement Undergoing Hip Arthroscopy: Analysis of a Claims Database.

抑郁和焦虑与接受髋关节镜检查的股骨髋臼撞击患者的医疗费用增加和阿片类药物使用有关：索赔数据库分析。

• 发表时间: 2020
• 作者: Jacobs, Cale A;Hawk, Greg S;Jochimsen, Kate N;Conley, Caitlin E;Vranceanu, Ana;Thompson, Katherine L;Duncan, Stephen T
• 通讯作者: Duncan, Stephen T

Republished: A lumbar arteriovenous fistula presenting with intraventricular hemorrhage and hydrocephalus.

重新发布：腰椎动静脉瘘，表现为脑室内出血和脑积水。

• 发表时间: 2020-05
• 作者: Miller, Brandon A;Spears, Robert Christopher;Hines, Thomas K;Alhajeri, Abdulnasser;Fraser, Justin F
• 通讯作者: Fraser, Justin F

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones.

广谱抗真菌剂：氟化芳基和杂芳基取代的腙。

• 发表时间: 2021-01-08
• 影响因子: 3.4
• 作者: Thamban Chandrika, Nishad;Dennis, Emily K;Brubaker, Katelyn R;Kwiatkowski, Stefan;Watt, David S;Garneau
• 通讯作者: Garneau