Third Coast Center For AIDS Research

第三海岸艾滋病研究中心

• 批准号: 10912108
• 负责人: Richard D'Aquila
• 金额: $ 23.06万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-09 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10912108
• 关键词: AIDS prevention; Acceleration; Acquired Immunodeficiency Syndrome; Adherence; African American; Aging; Aquila; Behavioral; Behavioral Sciences; Biological Assay; Biological Markers; Blood; Caring; Cells; Chicago; Clinical; Clinical Sciences; Collaborations; Communities; Consultations; Data Analytics; Data Science; Development; Diagnostic; Discipline; Disease; Disease remission; Doctor of Philosophy; Engineering; Epidemic; Foundations; Funding; Growth; HIV; Health; Health Professional; Heart; Illinois; Image; Immunity; Informatics; Infrastructure; Institution; Intervention; Magic; Market Research; Mentored Clinical Scientist Development Program; Mentors; Mission; Modeling; National Heart, Lung, and Blood Institute; Outcome; Partnership Practice; Persons; Populations at Risk; Prevention; Probability; Productivity; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Science; Scientist; Sleep; Social Sciences; Solid; Specimen; Speed; Strategic Planning; Systems Biology; Technology; Testing; Translational Research; Universities; Viral; Viral Pathogenesis; Viremia; Vulnerable Populations; Work; base; clinical phenotype; cohort; community engagement; community organizations; comorbidity; design; effective intervention; empowerment; health data; healthspan; implementation science; improved; innovation; interdisciplinary collaboration; men; multidisciplinary; pre-exposure prophylaxis; programs; recruit; social; success; synergism; transgender women; translational pipeline; virology; working group; young men who have sex with men

PROJECT SUMMARY THIRD COAST CFAR: OVERALL The broad, long-term mission of the Third Coast Center for AIDS Research (TC CFAR) is to use our trans-disciplinary collaborations to power transformational advances across the translational spectrum from discovery to implementation of effective interventions - and end HIV. Many local resources at Northwestern University (UC), the University of Chicago (UC), and community partners have been, and will continue to be, brought to bear on this mission. The allowable Funded Research Base (FRB) increased by 47%, and projects became more trans-disciplinary, from FY14 to FY18. Nimble and opportunistic strategic planning (by the Administrative Core, AC) and robust growth in seed funding and mentoring programs (by the Developmental Core, DC) led to those successes, and to choosing specific, high-priority HIV research topics as foci for a second term. Institutional support has increased. The Overall scientific aims were also chosen based on each of the 3 scientific Cores having a user base and expert resources with strengths on each aim. Each of these Cores has also worked to extend their resources and expertise to researchers outside their own domains, and thereby helped build collaborations. The following Overall aims build on our solid foundation, and will direct each scientific Core, in concert with the AC and the DC, to synergistically advance the science needed to end HIV. Overall Aim 1: To continue and expand collaborative research that will slow, and eventually stop, the HIV epidemic by improving continuums of HIV prevention and care. Overall Aim 2: To advance understanding of accelerated aging-related illnesses (non-AIDS comorbidities) that occur despite suppression of HIV viremia. Overall Aim 3: To speed discovery and empower development of transformative scientific innovations that will improve HIV prevention and treatment for persons living with HIV.

项目概要 第三海岸 CFAR：总体 第三海岸艾滋病研究中心 (TC CFAR) 广泛而长期的使命是利用我们的 跨学科合作，推动整个转化领域的转型进步 从发现到实施有效的干预措施，并消灭艾滋病毒。许多本地资源位于 西北大学 (UC)、芝加哥大学 (UC) 和社区合作伙伴已经，并且 将继续承担这一使命。允许的资助研究基地（FRB） 从 2014 财年到 2018 财年，项目数量增加了 47%，项目变得更加跨学科。敏捷和 机会主义战略规划（由行政核心，AC）和种子资金的强劲增长 和指导计划（由 DC 发展核心）带来了这些成功，并选择 特定的、高度优先的艾滋病毒研究主题作为第二个任期的重点。制度支持力度加大。 总体科学目标也是根据 3 个科学核心中每一个都有用户来选择的 基础和专家资源在每个目标上都有优势。每个核心还致力于扩展 他们向自己领域之外的研究人员提供资源和专业知识，从而帮助建立 合作。以下总体目标建立在我们坚实的基础上，并将指导每一项科学 Core 与 AC 和 DC 合作，协同推进终结艾滋病毒所需的科学。 总体目标 1：继续并扩大合作研究，这将减缓并最终阻止 通过改善艾滋病毒预防和护理的连续性来控制艾滋病毒流行。 总体目标 2：增进对加速衰老相关疾病（非艾滋病 尽管抑制了 HIV 病毒血症，但仍发生的并发症）。 总体目标 3：加速发现并促进变革性科学创新的发展 这将改善艾滋病毒感染者的艾滋病毒预防和治疗。